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Article

Endosymbiont Capture, a Repeated Process of Endosymbiont Transfer with Replacement in Trypanosomatids Angomonas spp.

1
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 České Budějovice (Budweis), Czech Republic
2
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
3
Life Science Research Centre, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
4
Faculty of Sciences, University of South Bohemia, 370 05 České Budějovice (Budweis), Czech Republic
5
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298-0678, USA
6
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
7
Martsinovsky Institute of Medical Parasitology, Sechenov University, 119435 Moscow, Russia
8
Zoological Institute of the Russian Academy of Sciences, 199034 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Bruno C. Lemaitre
Pathogens 2021, 10(6), 702; https://doi.org/10.3390/pathogens10060702
Received: 10 May 2021 / Revised: 31 May 2021 / Accepted: 1 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Kinetoplastid Phylogenomics and Evolution)
Trypanosomatids of the subfamily Strigomonadinae bear permanent intracellular bacterial symbionts acquired by the common ancestor of these flagellates. However, the cospeciation pattern inherent to such relationships was revealed to be broken upon the description of Angomonas ambiguus, which is sister to A. desouzai, but bears an endosymbiont genetically close to that of A. deanei. Based on phylogenetic inferences, it was proposed that the bacterium from A. deanei had been horizontally transferred to A. ambiguus. Here, we sequenced the bacterial genomes from two A. ambiguus isolates, including a new one from Papua New Guinea, and compared them with the published genome of the A. deanei endosymbiont, revealing differences below the interspecific level. Our phylogenetic analyses confirmed that the endosymbionts of A. ambiguus were obtained from A. deanei and, in addition, demonstrated that this occurred more than once. We propose that coinfection of the same blowfly host and the phylogenetic relatedness of the trypanosomatids facilitate such transitions, whereas the drastic difference in the occurrence of the two trypanosomatid species determines the observed direction of this process. This phenomenon is analogous to organelle (mitochondrion/plastid) capture described in multicellular organisms and, thereafter, we name it endosymbiont capture. View Full-Text
Keywords: genome; bacterial endosymbionts; Trypanosomatidae; Angomonas genome; bacterial endosymbionts; Trypanosomatidae; Angomonas
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MDPI and ACS Style

Skalický, T.; Alves, J.M.P.; Morais, A.C.; Režnarová, J.; Butenko, A.; Lukeš, J.; Serrano, M.G.; Buck, G.A.; Teixeira, M.M.G.; Camargo, E.P.; Sanders, M.; Cotton, J.A.; Yurchenko, V.; Kostygov, A.Y. Endosymbiont Capture, a Repeated Process of Endosymbiont Transfer with Replacement in Trypanosomatids Angomonas spp. Pathogens 2021, 10, 702. https://doi.org/10.3390/pathogens10060702

AMA Style

Skalický T, Alves JMP, Morais AC, Režnarová J, Butenko A, Lukeš J, Serrano MG, Buck GA, Teixeira MMG, Camargo EP, Sanders M, Cotton JA, Yurchenko V, Kostygov AY. Endosymbiont Capture, a Repeated Process of Endosymbiont Transfer with Replacement in Trypanosomatids Angomonas spp. Pathogens. 2021; 10(6):702. https://doi.org/10.3390/pathogens10060702

Chicago/Turabian Style

Skalický, Tomáš; Alves, João M.P.; Morais, Anderson C.; Režnarová, Jana; Butenko, Anzhelika; Lukeš, Julius; Serrano, Myrna G.; Buck, Gregory A.; Teixeira, Marta M.G.; Camargo, Erney P.; Sanders, Mandy; Cotton, James A.; Yurchenko, Vyacheslav; Kostygov, Alexei Y. 2021. "Endosymbiont Capture, a Repeated Process of Endosymbiont Transfer with Replacement in Trypanosomatids Angomonas spp." Pathogens 10, no. 6: 702. https://doi.org/10.3390/pathogens10060702

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