Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
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Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
2
Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, Canada
3
Department of Surgery, Queen’s University, Kingston, ON K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Sven Pischke
Pathogens 2021, 10(6), 685; https://doi.org/10.3390/pathogens10060685
Received: 5 May 2021 / Revised: 25 May 2021 / Accepted: 28 May 2021 / Published: 1 June 2021
(This article belongs to the Special Issue Hepatitis C Virus: Remaining Challenges)
Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection.
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Keywords:
hepatitis C virus; viral entry; glycans; vaccines; prophylaxis
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MDPI and ACS Style
LeBlanc, E.V.; Kim, Y.; Capicciotti, C.J.; Colpitts, C.C. Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies. Pathogens 2021, 10, 685. https://doi.org/10.3390/pathogens10060685
AMA Style
LeBlanc EV, Kim Y, Capicciotti CJ, Colpitts CC. Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies. Pathogens. 2021; 10(6):685. https://doi.org/10.3390/pathogens10060685
Chicago/Turabian StyleLeBlanc, Emmanuelle V., Youjin Kim, Chantelle J. Capicciotti, and Che C. Colpitts 2021. "Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies" Pathogens 10, no. 6: 685. https://doi.org/10.3390/pathogens10060685
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