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Volume 10
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10.3390/pathogens10050615
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Article

Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns’ Nasal Cavities

by
Carolina Cason
1,2,
Maria D’Accolti
3,4,
Giuseppina Campisciano
1,
Irene Soffritti
3,4,
Giuliano Ponis
1,
Sante Mazzacane
4,
Adele Maggiore
5,
Francesco Maria Risso
6,
Manola Comar
1,2,* and
Elisabetta Caselli
3,4
1
Department of Advanced Translational Microbiology, Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
2
Department of Medical Sciences, University of Trieste, 34137 Trieste, Italy
3
Department of Chemical and Pharmaceutical Sciences, Section of Microbiology and LTTA, University of Ferrara, 44121 Ferrara, Italy
4
CIAS Research Centre, University of Ferrara, 44122 Ferrara, Italy
5
Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
6
Department of Neonatology, Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
*
Author to whom correspondence should be addressed.
Pathogens 2021, 10(5), 615; https://doi.org/10.3390/pathogens10050615
Submission received: 12 March 2021 / Revised: 29 April 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Healthcare-Associated Infections)
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Abstract

Infants born before 28 weeks are at risk of contracting healthcare-associated infections (HAIs), which could be caused by pathogens residing on contaminated hospital surfaces. In this longitudinal study, we characterized by NGS the bacterial composition of nasal swabs of preterm newborns, at the time of birth and after admission to the Neonatal Intensive Care Unit (NICU), comparing it with that of the environmental wards at the time of delivery and during the hospitalization. We characterized the resistome on the samples too. The results showed that environmental microorganisms responsible for HAIs, in particular Staphylococcus spp., Streptococcus spp., Escherichia-Shigella spp., and K. pneumoniae, were detected in higher percentages in the noses of the babies after 13 days of hospitalization, in terms of the number of colonized patients, microorganism amount, and relative abundance. The analysis of nasal bacteria resistome evidenced the absence of resistance genes at the time of birth, some of which appeared and increased after the admission in the NICU. These data suggest that hospital surface microbiota might be transported to respiratory mucosae or other profound tissues. Our study highlights the importance of a screening that allows characterizing the microbial profile of the environment to assess the risk of colonization of the newborn.
Keywords: healthcare associated infections; preterm newborns; antimicrobial resistance genes; microbiome; environmental microbial contamination healthcare associated infections; preterm newborns; antimicrobial resistance genes; microbiome; environmental microbial contamination

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MDPI and ACS Style

Cason, C.; D’Accolti, M.; Campisciano, G.; Soffritti, I.; Ponis, G.; Mazzacane, S.; Maggiore, A.; Risso, F.M.; Comar, M.; Caselli, E. Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns’ Nasal Cavities. Pathogens 2021, 10, 615. https://doi.org/10.3390/pathogens10050615

AMA Style

Cason C, D’Accolti M, Campisciano G, Soffritti I, Ponis G, Mazzacane S, Maggiore A, Risso FM, Comar M, Caselli E. Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns’ Nasal Cavities. Pathogens. 2021; 10(5):615. https://doi.org/10.3390/pathogens10050615

Chicago/Turabian Style

Cason, Carolina, Maria D’Accolti, Giuseppina Campisciano, Irene Soffritti, Giuliano Ponis, Sante Mazzacane, Adele Maggiore, Francesco Maria Risso, Manola Comar, and Elisabetta Caselli. 2021. "Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns’ Nasal Cavities" Pathogens 10, no. 5: 615. https://doi.org/10.3390/pathogens10050615

APA Style

Cason, C., D’Accolti, M., Campisciano, G., Soffritti, I., Ponis, G., Mazzacane, S., Maggiore, A., Risso, F. M., Comar, M., & Caselli, E. (2021). Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns’ Nasal Cavities. Pathogens, 10(5), 615. https://doi.org/10.3390/pathogens10050615

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