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Article

PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon

1
Laboratorio de Malaria, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, 15102, Lima, Peru
2
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
3
Research Institute of Health and Society (IRSS). Université Catholique de Louvain, Clos Chapelle-aux-champs 30/B1.30.14 1200 Woluwe-Saint-Lambert, Brussels 1200, Belgium
4
Malaria: Parasites and Hosts Unit, Institut Pasteur, Paris 75015, France
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Sorbonne Université, Faculté des Sciences et Ingénierie, École Doctorale Pierre Louis - Santé Publique, Campus des Cordeliers, ED 393, F-75005 Paris, France
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Laboratorio de Malaria: Parásitos y Vectores, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
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Laboratorio ICEMR-Amazonia, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
8
Leishmania and Malaria Research Unit. Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
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Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
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Departamento de Ciencias Celulares y Moleculares, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
*
Author to whom correspondence should be addressed.
Equally contributed to this work.
Academic Editor: Kamala Ley-Thriemer
Pathogens 2021, 10(3), 282; https://doi.org/10.3390/pathogens10030282
Received: 30 January 2021 / Revised: 24 February 2021 / Accepted: 24 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Addressing Plasmodium vivax: From Control to Elimination)
The measurement of recent malaria exposure can support malaria control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker of recent exposure to P. vivax (Pv) in the Peruvian Amazon. In a first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex in a cohort of 422 Amazonian individuals with known history of Pv exposure (monthly data of infection status by qPCR and/or microscopy over five months). Both serological responses were able to discriminate between exposed and non-exposed individuals in a good manner, with slightly higher performance of anti-PvMSP10 IgGs (area under the curve AUC = 0.78 [95% CI = 0.72–0.83]) than anti-PvMSP8 IgGs (AUC = 0.72 [95% CI = 0.67–0.78]) (p = 0.01). In a second evaluation, the analysis by ELISA of 1251 plasma samples, collected during a population-based cross-sectional survey, confirmed the good performance of anti-PvMSP8 IgGs for discriminating between individuals with Pv infection at the time of survey and/or with antecedent of Pv in the past month (AUC = 0.79 [95% CI = 0.74–0.83]). Anti-PvMSP8 IgG antibodies can be considered as a good biomarker of recent Pv exposure in low-moderate transmission settings of the Peruvian Amazon. View Full-Text
Keywords: PvMSP8; antibodies; P. vivax; Luminex; ELISA; malaria PvMSP8; antibodies; P. vivax; Luminex; ELISA; malaria
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MDPI and ACS Style

Villasis, E.; Garro, K.; Rosas-Aguirre, A.; Rodriguez, P.; Rosado, J.; Gave, A.; Guzman-Guzman, M.; Manrique, P.; White, M.; Speybroeck, N.; Vinetz, J.M.; Torres, K.; Gamboa, D. PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon. Pathogens 2021, 10, 282. https://doi.org/10.3390/pathogens10030282

AMA Style

Villasis E, Garro K, Rosas-Aguirre A, Rodriguez P, Rosado J, Gave A, Guzman-Guzman M, Manrique P, White M, Speybroeck N, Vinetz JM, Torres K, Gamboa D. PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon. Pathogens. 2021; 10(3):282. https://doi.org/10.3390/pathogens10030282

Chicago/Turabian Style

Villasis, Elizabeth, Katherine Garro, Angel Rosas-Aguirre, Pamela Rodriguez, Jason Rosado, Anthony Gave, Mitchel Guzman-Guzman, Paulo Manrique, Michael White, Niko Speybroeck, Joseph M. Vinetz, Katherine Torres, and Dionicia Gamboa. 2021. "PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon" Pathogens 10, no. 3: 282. https://doi.org/10.3390/pathogens10030282

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