Next Article in Journal
Impact of the Peptide WMR-K on Dual-Species Biofilm Candida albicans/Klebsiella pneumoniae and on the Untargeted Metabolomic Profile
Previous Article in Journal
Assessing Trypanosoma cruzi Parasite Diversity through Comparative Genomics: Implications for Disease Epidemiology and Diagnostics
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 10
Issue 2
10.3390/pathogens10020213
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia

by
Shujie Wang
1,*,
Defu Zhang
2,†,
Chenggang Jiang
1,†,
Haijuan He
1,3,
Chenchen Cui
1,
Weitong Duan
1,
Shouping Hu
1,
Jun Wang
4 and
Xuehui Cai
1,*
1
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
2
College of Food Science and Technology, Bohai University, Jinzhou 121013, China
3
Institute of Animal Husbandry, Heilongjiang Academy of Agriculture Sciences, Harbin 150086, China
4
Beijing General Station of Animal Husbandry, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally.
Pathogens 2021, 10(2), 213; https://doi.org/10.3390/pathogens10020213
Submission received: 21 December 2020 / Revised: 7 February 2021 / Accepted: 12 February 2021 / Published: 16 February 2021
Browse Figures
Versions Notes

Abstract

Streptococcus suis causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of a multidrug-resistant S. suis serotype 28 (strain 11313) and a multidrug-resistant S. suis serotype 31 (strain 11LB5). Strain 11313 was apathogenic in mouse infection models, whereas strain 11LB5 displayed ganglion demyelination, meningeal thickening, congestion, mononuclear cell infiltration, massive proliferation of cortical glial cells, and bacteria (>104 CFU/g) in the spinal cord and ganglia in mice. Furthermore, immunohistochemistry found that the heavily infiltrated glial cells were astrocytes. Strain 11313 harbored the resistance genes ant(6)-Ia, erm(B), optrA, tet(l), tet(o), and strain 11LB5 harbored the resistance genes ant(6)-Ia, erm(B), tet(40), tet(o/w/32/o), aac(6′)-aph(2″). Mouse studies showed that strain 11LB5 exhibited a similar virulence to serotype 2 strain 700794, highlighting the need for surveillance of the other serotype S. suis isolates, in addition to serotype 2, in farms. This is the first report of the aminoglycoside resistance gene ant(6)-Ia in S. suis from animals. This suggests that S. suis might serve as an antibiotic resistance reservoir, which spreads the resistance gene ant(6)-Ia or optrA to other streptococcal pathogens on farms.
Keywords: Streptococcus suis serotype 28; Streptococcus suis serotype 31; characterization; genome; antibiotic resistance Streptococcus suis serotype 28; Streptococcus suis serotype 31; characterization; genome; antibiotic resistance

Share and Cite

MDPI and ACS Style

Wang, S.; Zhang, D.; Jiang, C.; He, H.; Cui, C.; Duan, W.; Hu, S.; Wang, J.; Cai, X. Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia. Pathogens 2021, 10, 213. https://doi.org/10.3390/pathogens10020213

AMA Style

Wang S, Zhang D, Jiang C, He H, Cui C, Duan W, Hu S, Wang J, Cai X. Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia. Pathogens. 2021; 10(2):213. https://doi.org/10.3390/pathogens10020213

Chicago/Turabian Style

Wang, Shujie, Defu Zhang, Chenggang Jiang, Haijuan He, Chenchen Cui, Weitong Duan, Shouping Hu, Jun Wang, and Xuehui Cai. 2021. "Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia" Pathogens 10, no. 2: 213. https://doi.org/10.3390/pathogens10020213

APA Style

Wang, S., Zhang, D., Jiang, C., He, H., Cui, C., Duan, W., Hu, S., Wang, J., & Cai, X. (2021). Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia. Pathogens, 10(2), 213. https://doi.org/10.3390/pathogens10020213

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop