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Article

Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing

1
Infectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
2
Microbiology Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
*
Author to whom correspondence should be addressed.
Academic Editors: Sheng-Fan Wang, Wen-Hung Wang and Arunee Thitithanyanont
Pathogens 2021, 10(11), 1399; https://doi.org/10.3390/pathogens10111399
Received: 8 October 2021 / Revised: 26 October 2021 / Accepted: 27 October 2021 / Published: 28 October 2021
(This article belongs to the Collection Emerging and Re-emerging Pathogens)
(1) Background: Leclercia adecarboxylata (L. adecarboxylata) is a gram-negative bacillus of the Enterobacteriaceae family, which is uncommonly isolated from clinical specimens. L. adecarboxylata is considered as an aquatic opportunistic pathogen and most of the human infections are polymicrobial and usually occur in immunocompromised hosts. (2) Methods: In this retrospective study, we included all L. adecarboxylata strains since the introduction of MALDI-TOF MS in the Microbiology Department of Nord Franche-Comté Hospital, France (from 1 March 2015 to 31 July 2019). We studied demographic characteristics, comorbidities, characteristics of the current infection and outcome as well as antimicrobial susceptibility testing in all isolates. (3) Results: A total of 8 samples were identified (in 6 patients (4M/2F), with a recurrent L. adecarboxylata infection in 2 patients). The patients’ mean age was 66.2 years (range: 19–84). All patients were considered as immunocompetent, except a peritoneal dialysis patient with kidney transplantation. An exposition to an aquatic environment was identified in one patient. The most prevalent clinical feature was catheter-associated male urinary tract infection (in 3 cases) followed by ventilator-associated pneumonia (in 2 cases). One of 6 patients presented L. adecarboxylata bacteremia. L. adecarboxylata was part of a polymicrobial infection in 4 patients. The isolates showed a high susceptibility to all tested antibiotics, except one strain, which was resistant to fosfomycin. All patients with L. adecarboxylata infection were treated with antibiotics with a favorable outcome. (4) Conclusion: This study confirms the pathogenicity of L. adecarboxylata, even in immunocompetent patients, with a high susceptibility to antibiotics. View Full-Text
Keywords: Leclercia adecarboxylata; emerging pathogen; MALDI-TOF; clinical features; antimicrobial susceptibility Leclercia adecarboxylata; emerging pathogen; MALDI-TOF; clinical features; antimicrobial susceptibility
MDPI and ACS Style

Zayet, S.; Lang, S.; Garnier, P.; Pierron, A.; Plantin, J.; Toko, L.; Royer, P.-Y.; Villemain, M.; Klopfenstein, T.; Gendrin, V. Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing. Pathogens 2021, 10, 1399. https://doi.org/10.3390/pathogens10111399

AMA Style

Zayet S, Lang S, Garnier P, Pierron A, Plantin J, Toko L, Royer P-Y, Villemain M, Klopfenstein T, Gendrin V. Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing. Pathogens. 2021; 10(11):1399. https://doi.org/10.3390/pathogens10111399

Chicago/Turabian Style

Zayet, Souheil, Stephane Lang, Pauline Garnier, Alix Pierron, Julie Plantin, Lynda Toko, Pierre-Yves Royer, Marc Villemain, Timothée Klopfenstein, and Vincent Gendrin. 2021. "Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing" Pathogens 10, no. 11: 1399. https://doi.org/10.3390/pathogens10111399

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