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Article

Swine Conjunctivitis Associated with a Novel Mycoplasma Species Closely Related to Mycoplasma hyorhinis

1
Field Station for Epidemiology in Bakum, University of Veterinary Medicine Hannover, 49456 Bakum, Germany
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Tierärztliche Gemeinschaftspraxis Büren FGS-GmbH, 33142 Büren, Germany
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Lower Saxony State Office for Consumer Protection and Food Safety, Food and Veterinary Institute Braunschweig/Hannover, 30173 Hannover, Germany
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Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, 1096 Vienna, Austria
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Institute of Microbiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
*
Author to whom correspondence should be addressed.
Pathogens 2021, 10(1), 13; https://doi.org/10.3390/pathogens10010013
Received: 19 October 2020 / Revised: 18 December 2020 / Accepted: 23 December 2020 / Published: 25 December 2020
(This article belongs to the Section Animal Pathogens)
Conjunctivitis in swine is a common finding, usually considered to be a secondary symptom of respiratory or viral systemic disease, or a result of irritation by dust or ammonia, or of local infections with Mycoplasma (M.) hyorhinis or chlamydia. In three unrelated swine farms in Germany with a high prevalence of conjunctivitis, a novel mycoplasma species, tentatively named Mycoplasma sp. 1654_15, was isolated from conjunctival swabs taken from affected pigs. Although 16S rRNA gene sequences shared highest nucleotide similarities with M. hyorhinis, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry, partial rpoB sequencing, and comparative whole genome analyses indicated the identification of a novel species within genus Mycoplasma. Noticeable differences between Mycoplasma sp. 1654_15 and M. hyorhinis were the lack of a vlp locus and the presence of a myo-inositol pathway in the genome of strain 1654_15. Since myo-inositol might be used as an alternative energy source by this pathogen on the conjunctival surface, robust colonization by outcompeting other bacteria could be the consequence. In summary, abundant isolation of Mycoplasma sp. 1654_15 from the conjunctiva of affected pigs, its close relationship to M. hyorhinis, and identification of a panel of coding sequences (CDSs) potentially associated with virulence and pathogenicity suggested a local eye disease caused by a so far unknown, highly specialized mycoplasma species. View Full-Text
Keywords: ammonia; conjunctivitis; lymphohistiocytic inflammation; Mycoplasma sp. nov.; myo-inositol pathway; swine ammonia; conjunctivitis; lymphohistiocytic inflammation; Mycoplasma sp. nov.; myo-inositol pathway; swine
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MDPI and ACS Style

Hennig-Pauka, I.; Sudendey, C.; Kleinschmidt, S.; Ruppitsch, W.; Loncaric, I.; Spergser, J. Swine Conjunctivitis Associated with a Novel Mycoplasma Species Closely Related to Mycoplasma hyorhinis. Pathogens 2021, 10, 13. https://doi.org/10.3390/pathogens10010013

AMA Style

Hennig-Pauka I, Sudendey C, Kleinschmidt S, Ruppitsch W, Loncaric I, Spergser J. Swine Conjunctivitis Associated with a Novel Mycoplasma Species Closely Related to Mycoplasma hyorhinis. Pathogens. 2021; 10(1):13. https://doi.org/10.3390/pathogens10010013

Chicago/Turabian Style

Hennig-Pauka, Isabel, Christoph Sudendey, Sven Kleinschmidt, Werner Ruppitsch, Igor Loncaric, and Joachim Spergser. 2021. "Swine Conjunctivitis Associated with a Novel Mycoplasma Species Closely Related to Mycoplasma hyorhinis" Pathogens 10, no. 1: 13. https://doi.org/10.3390/pathogens10010013

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