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Open AccessArticle

The Effects of Various Metallic Surfaces on Cellular and Bacterial Adhesion

1
Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
2
Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
3
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
4
Research Center for Structural Materials, National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan
5
Department of Anatomy, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto, Chikusa-ku, Nagoya 464-8650, Japan
*
Author to whom correspondence should be addressed.
Metals 2019, 9(11), 1145; https://doi.org/10.3390/met9111145
Received: 22 September 2019 / Revised: 18 October 2019 / Accepted: 23 October 2019 / Published: 25 October 2019
(This article belongs to the Special Issue Metallic Biomaterials Surface Engineering)
The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion. View Full-Text
Keywords: titanium; niobium; tantalum; zirconium; silver; β-stabilizer elements; antibacterial activity; biocompatibility; cytotoxicity; biofilm titanium; niobium; tantalum; zirconium; silver; β-stabilizer elements; antibacterial activity; biocompatibility; cytotoxicity; biofilm
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Shimabukuro, M.; Ito, H.; Tsutsumi, Y.; Nozaki, K.; Chen, P.; Yamada, R.; Ashida, M.; Nagai, A.; Hanawa, T. The Effects of Various Metallic Surfaces on Cellular and Bacterial Adhesion. Metals 2019, 9, 1145.

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