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Epigenomes
Volume 7
Issue 1
10.3390/epigenomes7010006
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Review

Epigenetic Regulation in Breast Cancer: Insights on Epidrugs

by
Ayoung Kim
1,†,
Kyumin Mo
1,†,
Hyeonseok Kwon
1,†,
Soohyun Choe
1,
Misung Park
1,2,
Woori Kwak
1,2,* and
Hyunho Yoon
1,2,*
1
Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea
2
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Epigenomes 2023, 7(1), 6; https://doi.org/10.3390/epigenomes7010006
Submission received: 12 January 2023 / Revised: 16 February 2023 / Accepted: 17 February 2023 / Published: 18 February 2023
(This article belongs to the Special Issue Epidrugs: Toward Understanding and Treating Diverse Diseases)
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Abstract

Breast cancer remains a common cause of cancer-related death in women. Therefore, further studies are necessary for the comprehension of breast cancer and the revolution of breast cancer treatment. Cancer is a heterogeneous disease that results from epigenetic alterations in normal cells. Aberrant epigenetic regulation is strongly associated with the development of breast cancer. Current therapeutic approaches target epigenetic alterations rather than genetic mutations due to their reversibility. The formation and maintenance of epigenetic changes depend on specific enzymes, including DNA methyltransferases and histone deacetylases, which are promising targets for epigenetic-based therapy. Epidrugs target different epigenetic alterations, including DNA methylation, histone acetylation, and histone methylation, which can restore normal cellular memory in cancerous diseases. Epigenetic-targeted therapy using epidrugs has anti-tumor effects on malignancies, including breast cancer. This review focuses on the importance of epigenetic regulation and the clinical implications of epidrugs in breast cancer.
Keywords: epigenetic regulation; epidrug; breast cancer; DNMT; HDAC epigenetic regulation; epidrug; breast cancer; DNMT; HDAC

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MDPI and ACS Style

Kim, A.; Mo, K.; Kwon, H.; Choe, S.; Park, M.; Kwak, W.; Yoon, H. Epigenetic Regulation in Breast Cancer: Insights on Epidrugs. Epigenomes 2023, 7, 6. https://doi.org/10.3390/epigenomes7010006

AMA Style

Kim A, Mo K, Kwon H, Choe S, Park M, Kwak W, Yoon H. Epigenetic Regulation in Breast Cancer: Insights on Epidrugs. Epigenomes. 2023; 7(1):6. https://doi.org/10.3390/epigenomes7010006

Chicago/Turabian Style

Kim, Ayoung, Kyumin Mo, Hyeonseok Kwon, Soohyun Choe, Misung Park, Woori Kwak, and Hyunho Yoon. 2023. "Epigenetic Regulation in Breast Cancer: Insights on Epidrugs" Epigenomes 7, no. 1: 6. https://doi.org/10.3390/epigenomes7010006

APA Style

Kim, A., Mo, K., Kwon, H., Choe, S., Park, M., Kwak, W., & Yoon, H. (2023). Epigenetic Regulation in Breast Cancer: Insights on Epidrugs. Epigenomes, 7(1), 6. https://doi.org/10.3390/epigenomes7010006

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