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Open AccessEditorial

Non-CpG Methylation Revised

Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324-00161 Rome, Italy
Epigenomes 2018, 2(4), 22;
Received: 30 November 2018 / Accepted: 11 December 2018 / Published: 12 December 2018
(This article belongs to the Special Issue Epigenetics of the Nervous System)
PDF [176 KB, uploaded 12 December 2018]


Textbook and scientific papers addressing DNA methylation usually still cite “DNA methylation occurs at CpG cytosines”. Methylation at cytosines outside the CpG nucleotide, the so-called “non-CpG methylation”, is usually considered a minor and not biologically relevant process. However, the technical improvements and additional studies in epigenetics have demonstrated that non-CpG methylation is present with frequency higher than previously thought and retains biological activity, potentially relevant to the understanding and the treatment of human diseases. View Full-Text
Keywords: DNA methylation; non-CpG methylation; DNMT3; bisulfite assay; neuroepigenetics DNA methylation; non-CpG methylation; DNMT3; bisulfite assay; neuroepigenetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fuso, A. Non-CpG Methylation Revised. Epigenomes 2018, 2, 22.

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