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Article

The Journey of Acromegaly Towards Treatment: A Single-Center Study

by
Varvara Chalmantzi
1,
Sophia Vlachou
2,
Maria Eleni Chondrogianni
2,
Maria Panagaki
2,
Ariadni Spyroglou
3,
Marina Tsoli
2,
Eva Kassi
2,
Gregory Kaltsas
2 and
Krystallenia I. Alexandraki
3,*
1
Unit of Endocrinology, First Department of Internal Medicine, Laikon Hospital, 11527 Athens, PC, Greece
2
First Department of Propaedeutic Internal Medicine, Laikon Hospital, National & Kapodistrian University of Athens, 11527 Athens, PC, Greece
3
Second Department of Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, PC, Greece
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2026, 16(2), 85; https://doi.org/10.3390/jpm16020085
Submission received: 19 October 2025 / Revised: 8 December 2025 / Accepted: 14 January 2026 / Published: 2 February 2026
(This article belongs to the Section Personalized Therapy in Clinical Medicine)
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Abstract

Background: In the era of personalized medicine, the overall therapeutic approach has progressed throughout the years in acromegaly, but biochemical control of the disease is not achieved in a significant proportion of patients. This study aims to systematically record the journey of patients with acromegaly in the context of adenomas characteristics, therapeutic approaches and comorbidities in acromegaly with an emphasis in elderly. Method: In this retrospective study 79 patients were diagnosed with acromegaly between 1971 and 2023. Results: The dataset consisted of 43 (54%) female and 36 male (46%) with an overall mean age ± SD at diagnosis at 45 ± 13 years. 57 (73%) underwent one surgical procedure. Medical treatment with one agent was reported in 36 patients (67%), almost all by somatostatin analogs (89%). Radiotherapy was offered in 14 patients (18%). Disease remission was documented in 67 (85%) patients. IGF1/ULN at diagnosis displayed a tendency to predict non-remission. A diagnostic delay of less than five years was reported in 28 cases (65%) and patients reporting longer delays were older at diagnosis (58 ± 6 years). Patients diagnosed at or above the age of 60 were less likely to undergo a surgical procedure compared to patients diagnosed before the age of 60. Conclusions: Biochemical control was the most frequent disease outcome. A higher IGF-1/ULN ratio tends to predict non-remission. Longer diagnostic delay was reported with advancing age and older patients were less likely to follow surgical procedures.
Keywords: acromegaly; IGF-1; adenoma; biochemical control; elderly; comorbidities; neoplasia acromegaly; IGF-1; adenoma; biochemical control; elderly; comorbidities; neoplasia

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MDPI and ACS Style

Chalmantzi, V.; Vlachou, S.; Chondrogianni, M.E.; Panagaki, M.; Spyroglou, A.; Tsoli, M.; Kassi, E.; Kaltsas, G.; Alexandraki, K.I. The Journey of Acromegaly Towards Treatment: A Single-Center Study. J. Pers. Med. 2026, 16, 85. https://doi.org/10.3390/jpm16020085

AMA Style

Chalmantzi V, Vlachou S, Chondrogianni ME, Panagaki M, Spyroglou A, Tsoli M, Kassi E, Kaltsas G, Alexandraki KI. The Journey of Acromegaly Towards Treatment: A Single-Center Study. Journal of Personalized Medicine. 2026; 16(2):85. https://doi.org/10.3390/jpm16020085

Chicago/Turabian Style

Chalmantzi, Varvara, Sophia Vlachou, Maria Eleni Chondrogianni, Maria Panagaki, Ariadni Spyroglou, Marina Tsoli, Eva Kassi, Gregory Kaltsas, and Krystallenia I. Alexandraki. 2026. "The Journey of Acromegaly Towards Treatment: A Single-Center Study" Journal of Personalized Medicine 16, no. 2: 85. https://doi.org/10.3390/jpm16020085

APA Style

Chalmantzi, V., Vlachou, S., Chondrogianni, M. E., Panagaki, M., Spyroglou, A., Tsoli, M., Kassi, E., Kaltsas, G., & Alexandraki, K. I. (2026). The Journey of Acromegaly Towards Treatment: A Single-Center Study. Journal of Personalized Medicine, 16(2), 85. https://doi.org/10.3390/jpm16020085

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