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Volume 14
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10.3390/jpm14060611
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Article

Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience

by
Melina Danisch
1,
Marlene Kranawetter
1,
Thomas Bartl
1,*,
Magdalena Postl
1,
Christoph Grimm
1,
Eva Langthaler
2 and
Stephan Polterauer
1,3
1
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria
2
Department of Pathology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria
3
Karl Landsteiner Institute for General Gynecology and Experimental Gynecologic Oncology, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2024, 14(6), 611; https://doi.org/10.3390/jpm14060611
Submission received: 15 May 2024 / Revised: 4 June 2024 / Accepted: 5 June 2024 / Published: 8 June 2024
(This article belongs to the Section Mechanisms of Diseases)
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Abstract

Radical trachelectomy allows for fertility preservation in patients with early cervical cancer not qualifying as “low-risk” as defined by ConCerv. This study reports on the 10-year surgical, oncological, and obstetrical experience of patients treated by radical abdominal trachelectomy at an Austrian tertiary care center. A retrospective chart analysis and telephone survey of all patients with FIGO stage IA2-IB2 (2018) cervical cancer treated by radical abdominal trachelectomy and pelvic lymphadenectomy between 2013 and 2022 were performed. Radical abdominal trachelectomy was attempted in 29 patients, of whom 3 patients underwent neoadjuvant chemotherapy. Three cases, including one after neoadjuvant therapy, required conversion to radical hysterectomy due to positive margins; four cases had positive lymph nodes following surgical staging and were referred to primary chemo-radiotherapy. Twenty-two (75.9%) successful abdominal radical trachelectomies preserving fertility were performed. According to final histopathology, 79.3% of tumors would not have met the “low-risk”-criteria. At a median follow-up of 64.5 (25.5–104.0) months, no recurrence was observed. Eight (36.4%) patients attempted to conceive, with a live birth rate of 62.5%. Radical abdominal trachelectomy appears oncologically safe in early-stage cervical cancers that do not fulfill the “low-risk”-criteria. Strict preoperative selection of patients who might qualify for more conservative surgical approaches is strongly recommended.
Keywords: cervical cancer; radical abdominal trachelectomy; fertility preservation; oncological outcomes; fertility outcomes cervical cancer; radical abdominal trachelectomy; fertility preservation; oncological outcomes; fertility outcomes

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MDPI and ACS Style

Danisch, M.; Kranawetter, M.; Bartl, T.; Postl, M.; Grimm, C.; Langthaler, E.; Polterauer, S. Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience. J. Pers. Med. 2024, 14, 611. https://doi.org/10.3390/jpm14060611

AMA Style

Danisch M, Kranawetter M, Bartl T, Postl M, Grimm C, Langthaler E, Polterauer S. Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience. Journal of Personalized Medicine. 2024; 14(6):611. https://doi.org/10.3390/jpm14060611

Chicago/Turabian Style

Danisch, Melina, Marlene Kranawetter, Thomas Bartl, Magdalena Postl, Christoph Grimm, Eva Langthaler, and Stephan Polterauer. 2024. "Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience" Journal of Personalized Medicine 14, no. 6: 611. https://doi.org/10.3390/jpm14060611

APA Style

Danisch, M., Kranawetter, M., Bartl, T., Postl, M., Grimm, C., Langthaler, E., & Polterauer, S. (2024). Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience. Journal of Personalized Medicine, 14(6), 611. https://doi.org/10.3390/jpm14060611

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