The Impact of Chemotherapy and Transforming Growth Factor-β1 in Liver Regeneration after Hepatectomy among Colorectal Cancer Patients

Round 1

Reviewer 1 Report

Thanks for inviting me to evaluate the article titled ‘The Impact of Chemotherapy and Transforming Growth Factor-β1 in Liver Regeneration After Hepatectomy among Colorectal Cancer Patients’. In this paper, the authors demonstrated, this study focused on liver regeneration in CRLM patients’ post-chemotherapy. Additionally, they exhibited lower serum TGFβ-1 levels and reduced TGFβ-1 expression in liver tissue, suggesting TGFβ-1 involvement in mechanisms hindering liver regeneration capacity following major resection after chemotherapy. This paper is of novelty. While some parts of the text still need to be revised. Figure 2 is hard to see. Please provide a clear one. So, I recommend reconsidering this paper after minor revision.

Author Response

Dear reviewer, thank you for your response. High-resolution images will be provided in supplementary material.

Reviewer 2 Report

Dear authors,

Thanks for your outstanding work

However, there are a few remarks to be noted:

- Minor comments

1- What was that indication of hepatectomy in focal nodular hyperplasia?

N/B: It is "focal" not "follicular" as written by mistake in the manuscript

2- The resolution of the written text in Figure two must be improved

- Major comments:

3 - Please perform deeper statistical analysis if a certain chemotherapy regimen affected liver regeneration more than the other types

4- please mention the used immunotherapy types and perform statistical analysis also to see if a certain type has more affection than the others 

Author Response

Dear reviewer, thank you for your time and comments regarding manuscript.

1 - spelling mistake was corrected;

2 - resolution of text and figure was improved;

3 - deeper statistical analysis is not possible due to fairly small amount of cases;

4 - immunotherapy regimens were specified