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Volume 13
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10.3390/jpm13050839
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Background:
Systematic Review

Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke

by
Chiara Siracusa
1,
Niccolò Vono
1,
Maria Benedetta Morano
1,
Jolanda Sabatino
2,
Isabella Leo
3,4,
Ceren Eyileten
5,6,
Eleonora Cianflone
1,
Marek Postula
5,
Daniele Torella
4 and
Salvatore De Rosa
1,*
1
Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy
2
Department of Children and Woman’s Health, University of Padua, 35121 Padua, Italy
3
Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London SW3 5NP, UK
4
Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy
5
Centre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland
6
Genomics Core Facility, Center of New Technologies, University of Warsaw, 00-927 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2023, 13(5), 839; https://doi.org/10.3390/jpm13050839
Submission received: 17 April 2023 / Revised: 12 May 2023 / Accepted: 14 May 2023 / Published: 16 May 2023
(This article belongs to the Special Issue Diagnosis, Treatment and Prognosis of Cardiovascular Diseases 2.0)
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Abstract

Despite the substantial improvement in diagnosis and treatment within the last decades, ischemic stroke still represents a challenge, responsible still for a high burden of morbidity and mortality. Among the unmet clinical needs are the difficulties in identifying those subjects with the greatest risk of developing a stroke, the challenges in obtaining a timely diagnosis, the prompt recognition of the different clinical forms of stroke, the assessment of the response to treatments and the prognostic assessment. All these issues might be improved with appropriate smart biomarkers that could better inform clinical management. The present article offers an overview of the potential role of circular RNAs as disease biomarkers in stroke. A systematic approach was adopted to gather all potentially relevant information in order to provide a panoramic view on this class of promising molecules.
Keywords: stroke; ischemia; cerebrovascular disease; noncoding RNAs; circRNAs; biomarkers stroke; ischemia; cerebrovascular disease; noncoding RNAs; circRNAs; biomarkers

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MDPI and ACS Style

Siracusa, C.; Vono, N.; Morano, M.B.; Sabatino, J.; Leo, I.; Eyileten, C.; Cianflone, E.; Postula, M.; Torella, D.; De Rosa, S. Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke. J. Pers. Med. 2023, 13, 839. https://doi.org/10.3390/jpm13050839

AMA Style

Siracusa C, Vono N, Morano MB, Sabatino J, Leo I, Eyileten C, Cianflone E, Postula M, Torella D, De Rosa S. Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke. Journal of Personalized Medicine. 2023; 13(5):839. https://doi.org/10.3390/jpm13050839

Chicago/Turabian Style

Siracusa, Chiara, Niccolò Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, and Salvatore De Rosa. 2023. "Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke" Journal of Personalized Medicine 13, no. 5: 839. https://doi.org/10.3390/jpm13050839

APA Style

Siracusa, C., Vono, N., Morano, M. B., Sabatino, J., Leo, I., Eyileten, C., Cianflone, E., Postula, M., Torella, D., & De Rosa, S. (2023). Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke. Journal of Personalized Medicine, 13(5), 839. https://doi.org/10.3390/jpm13050839

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