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Article

Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer

by
Andrea Iandelli
1,2,3,†,
Filippo Marchi
2,3,4,†,
An-Chieh Chen
1,
Chi-Kuan Young
5,6,
Chun-Ta Liao
1,6,
Chung-Kan Tsao
4,6,
Chung-Jan Kang
1,6,
Hung-Ming Wang
6,7,
Tung-Chieh Joseph Chang
6,8 and
Shiang-Fu Huang
1,9,*
1
Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan
2
Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
3
Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16132 Genova, Italy
4
Department of Plastic Surgery, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan
5
Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Keelung Branch, Keelung 20401, Taiwan
6
School of Medicine, Chang Gung University, Taoyuan 333, Taiwan
7
Department of Medical Oncology, Internal Medicine, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan
8
Department of Radiation Oncology, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan
9
Graduate Institute of Clinical Medical Sciences, Chang Gun Medical College, Chang Gung University, Taoyuan 33302, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2022, 12(9), 1535; https://doi.org/10.3390/jpm12091535
Submission received: 28 August 2022 / Revised: 13 September 2022 / Accepted: 14 September 2022 / Published: 19 September 2022
(This article belongs to the Section Personalized Therapy in Clinical Medicine)
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Abstract

Background: Patients affected by oral tongue squamous cell carcinoma (OTSCC) underwent a supraomohyoid neck dissection (SOHND) or modified radical neck dissection (mRND) according to the clinical nodal status (cN0 vs. cN+). We investigate whether the type of neck dissection affects survival with the presence of extranodal extension (ENE) and multiple nodal metastases (MNM). Methods: We conducted a retrospective study enrolling surgically treated patients affected by cT1/T2 OTSCC and MNM or ENE. The outcomes assessed were: overall survival (OS), disease-free survival (DFS), and neck-control- and metastases-free survival (NC-MFS). Survival curves were plotted by the Kaplan–Meier method and the log-rank test. Furthermore, we conducted a multivariable analysis with the Cox regression model. Results: We included a total of 565 patients (36% cT1, 64% cT2). Of these, 501 patients underwent a SOHND, and 64 underwent an mRND. A total of 184 patients presented rpN+, with 28.7% of these in the SOHND group and 62.5% of these in the mRND group. We identified no significant differences in OS, DFS, and NC-MFS in the whole pN+ cohort, in the MNM, and the ENE subgroups. In the multivariable analysis, the type of ND did not affect OS and DFS. Conclusions: Treating cT1-2 N0/+ tongue cancer with SOHND is oncologically safe. ENE and MNM patients do not benefit from an mRND.
Keywords: oral cancer; tongue cancers; head and neck cancer; neck dissection; supraomohyoid neck dissection; skip metastases oral cancer; tongue cancers; head and neck cancer; neck dissection; supraomohyoid neck dissection; skip metastases

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MDPI and ACS Style

Iandelli, A.; Marchi, F.; Chen, A.-C.; Young, C.-K.; Liao, C.-T.; Tsao, C.-K.; Kang, C.-J.; Wang, H.-M.; Chang, T.-C.J.; Huang, S.-F. Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer. J. Pers. Med. 2022, 12, 1535. https://doi.org/10.3390/jpm12091535

AMA Style

Iandelli A, Marchi F, Chen A-C, Young C-K, Liao C-T, Tsao C-K, Kang C-J, Wang H-M, Chang T-CJ, Huang S-F. Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer. Journal of Personalized Medicine. 2022; 12(9):1535. https://doi.org/10.3390/jpm12091535

Chicago/Turabian Style

Iandelli, Andrea, Filippo Marchi, An-Chieh Chen, Chi-Kuan Young, Chun-Ta Liao, Chung-Kan Tsao, Chung-Jan Kang, Hung-Ming Wang, Tung-Chieh Joseph Chang, and Shiang-Fu Huang. 2022. "Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer" Journal of Personalized Medicine 12, no. 9: 1535. https://doi.org/10.3390/jpm12091535

APA Style

Iandelli, A., Marchi, F., Chen, A.-C., Young, C.-K., Liao, C.-T., Tsao, C.-K., Kang, C.-J., Wang, H.-M., Chang, T.-C. J., & Huang, S.-F. (2022). Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer. Journal of Personalized Medicine, 12(9), 1535. https://doi.org/10.3390/jpm12091535

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