Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance

Boice, Emily N.; Berard, David; Hernandez Torres, Sofia I.; Avital, Guy; Snider, Eric J.

doi:10.3390/jpm12081287

Open AccessArticle

Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance

by

Emily N. Boice

¹

,

David Berard

¹

,

Sofia I. Hernandez Torres

¹,

Guy Avital

^1,2,3

and

Eric J. Snider

^1,*

¹

U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA

²

Trauma & Combat Medicine Branch, Surgeon General’s Headquarters, Israel Defense Forces, Ramat-Gan 52620, Israel

³

Division of Anesthesia, Intensive Care & Pain Management, Tel-Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel

^*

Author to whom correspondence should be addressed.

J. Pers. Med. 2022, 12(8), 1287; https://doi.org/10.3390/jpm12081287

Submission received: 9 July 2022 / Revised: 31 July 2022 / Accepted: 3 August 2022 / Published: 5 August 2022

(This article belongs to the Special Issue Individualized Trauma Management and Care Strategy)

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Abstract

Access to the central vasculature is critical for hemodynamic monitoring and for delivery of life-saving therapeutics during emergency medicine and battlefield trauma situations but requires skill often unavailable in austere environments. Automated central vascular access devices (ACVADs) using ultrasound and robotics are being developed. Here, we present an ex vivo lower-body porcine model as a testing platform for evaluation of vascular devices and compare its features to commercially available platforms. While the commercially available trainers were simpler to set-up and use, the scope of their utility was limited as they were unable to provide realistic anatomic, physiologic, and sonographic properties that were provided by the ex vivo model. However, the ex vivo model was more cumbersome to set-up and use. Overall, both have a place in the development and evaluation pipeline for ACVADs before testing on live animals, thus accelerating product development and translation.

Keywords: model development; automation; ex vivo; porcine; femoral; vascular access device; medical devices

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MDPI and ACS Style

Boice, E.N.; Berard, D.; Hernandez Torres, S.I.; Avital, G.; Snider, E.J. Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance. J. Pers. Med. 2022, 12, 1287. https://doi.org/10.3390/jpm12081287

AMA Style

Boice EN, Berard D, Hernandez Torres SI, Avital G, Snider EJ. Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance. Journal of Personalized Medicine. 2022; 12(8):1287. https://doi.org/10.3390/jpm12081287

Chicago/Turabian Style

Boice, Emily N., David Berard, Sofia I. Hernandez Torres, Guy Avital, and Eric J. Snider. 2022. "Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance" Journal of Personalized Medicine 12, no. 8: 1287. https://doi.org/10.3390/jpm12081287

APA Style

Boice, E. N., Berard, D., Hernandez Torres, S. I., Avital, G., & Snider, E. J. (2022). Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance. Journal of Personalized Medicine, 12(8), 1287. https://doi.org/10.3390/jpm12081287

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance

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