The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations

Pastana, Lucas Favacho; Silva, Thays Amâncio; Gellen, Laura Patrícia Albarello; Vieira, Giovana Miranda; de Assunção, Letícia Almeida; Leitão, Luciana Pereira Colares; da Silva, Natasha Monte; Coelho, Rita de Cássia Calderaro; de Alcântara, Angélica Leite; Vinagre, Lui Wallacy Morikawa Souza; Rodrigues, Juliana Carla Gomes; Borges Leal, Diana Feio da Veiga; Fernandes, Marianne Rodrigues; de Souza, Sandro José; Kroll, José Eduardo; Ribeiro-dos-Santos, André Mauricio; Burbano, Rommel Mario Rodríguez; Guerreiro, João Farias; de Assumpção, Paulo Pimentel; Ribeiro-dos-Santos, Ândrea Campos; dos Santos, Sidney Emanuel Batista; dos Santos, Ney Pereira Carneiro

doi:10.3390/jpm12040554

Open AccessArticle

The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations

by

Lucas Favacho Pastana

¹,

Thays Amâncio Silva

¹,

Laura Patrícia Albarello Gellen

¹

,

Giovana Miranda Vieira

¹,

Letícia Almeida de Assunção

¹,

Luciana Pereira Colares Leitão

¹,

Natasha Monte da Silva

¹,

Rita de Cássia Calderaro Coelho

¹,

Angélica Leite de Alcântara

¹

,

Lui Wallacy Morikawa Souza Vinagre

¹

,

Juliana Carla Gomes Rodrigues

¹,

Diana Feio da Veiga Borges Leal

¹

,

Marianne Rodrigues Fernandes

¹

,

Sandro José de Souza

^2,3,4,

José Eduardo Kroll

²

,

André Mauricio Ribeiro-dos-Santos

⁵,

Rommel Mario Rodríguez Burbano

¹,

João Farias Guerreiro

⁵

,

Paulo Pimentel de Assumpção

¹,

Ândrea Campos Ribeiro-dos-Santos

⁵

,

Sidney Emanuel Batista dos Santos

¹

and

Ney Pereira Carneiro dos Santos

^1,* Show full author list Hide full author list

¹

Laboratório do Núcleo de Pesquisa em Oncologia, Universidade Federal do Pará, Belém 66073-000, Brazil

²

Instituto do Cérebro, Universidade Federal do Rio Grande do Norte, Natal 59076-550, Brazil

³

BioME, Universidade Federal do Rio Grande do Norte, Natal 59078-400, Brazil

⁴

Institute of Systems Genetics, West China Hospital, University of Sichuan, Chengdu 610041, China

⁵

Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66075-110, Brazil

^*

Author to whom correspondence should be addressed.

J. Pers. Med. 2022, 12(4), 554; https://doi.org/10.3390/jpm12040554

Submission received: 25 January 2022 / Revised: 11 February 2022 / Accepted: 15 February 2022 / Published: 1 April 2022

(This article belongs to the Special Issue Recent Advances on Coronavirus Disease 2019 (COVID-19))

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Abstract

Genetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1, and ABO genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study population was composed of 64 Amerindians from the Amazon region of northern Brazil. The difference in frequencies between the populations was analyzed using Fisher’s exact test, and the results were significant when p ≤ 0.05. We investigated 64 polymorphisms in 7 genes; we studied 47 genetic variants that were new or had impact predictions of high, moderate, or modifier. We identified 15 polymorphisms with moderate impact prediction in 4 genes (ABO, CXCR6, FYCO1, and SLC6A20). Among the variants analyzed, 18 showed significant differences in allele frequency in the NAM population when compared to others. We reported two new genetic variants with modifier impact in the Amazonian population that could be studied to validate the possible associations with COVID-19 outcomes. The genomic profile of Amazonian Native Americans may be associated with protection from severe forms of COVID-19. This work provides genomic data that may help forthcoming studies to improve COVID-19 outcomes.

Keywords: COVID-19; gene; risk factor; genetic variant

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MDPI and ACS Style

Pastana, L.F.; Silva, T.A.; Gellen, L.P.A.; Vieira, G.M.; de Assunção, L.A.; Leitão, L.P.C.; da Silva, N.M.; Coelho, R.d.C.C.; de Alcântara, A.L.; Vinagre, L.W.M.S.; et al. The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations. J. Pers. Med. 2022, 12, 554. https://doi.org/10.3390/jpm12040554

AMA Style

Pastana LF, Silva TA, Gellen LPA, Vieira GM, de Assunção LA, Leitão LPC, da Silva NM, Coelho RdCC, de Alcântara AL, Vinagre LWMS, et al. The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations. Journal of Personalized Medicine. 2022; 12(4):554. https://doi.org/10.3390/jpm12040554

Chicago/Turabian Style

Pastana, Lucas Favacho, Thays Amâncio Silva, Laura Patrícia Albarello Gellen, Giovana Miranda Vieira, Letícia Almeida de Assunção, Luciana Pereira Colares Leitão, Natasha Monte da Silva, Rita de Cássia Calderaro Coelho, Angélica Leite de Alcântara, Lui Wallacy Morikawa Souza Vinagre, and et al. 2022. "The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations" Journal of Personalized Medicine 12, no. 4: 554. https://doi.org/10.3390/jpm12040554

APA Style

Pastana, L. F., Silva, T. A., Gellen, L. P. A., Vieira, G. M., de Assunção, L. A., Leitão, L. P. C., da Silva, N. M., Coelho, R. d. C. C., de Alcântara, A. L., Vinagre, L. W. M. S., Rodrigues, J. C. G., Borges Leal, D. F. d. V., Fernandes, M. R., de Souza, S. J., Kroll, J. E., Ribeiro-dos-Santos, A. M., Burbano, R. M. R., Guerreiro, J. F., de Assumpção, P. P., ... dos Santos, N. P. C. (2022). The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations. Journal of Personalized Medicine, 12(4), 554. https://doi.org/10.3390/jpm12040554

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The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations

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