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Article

ILB® Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis

1
UniCamillus, Saint Camillus International University of Health Sciences, 00131 Rome, Italy
2
Department of Basic Biotechnological Sciences, Intensive and Perioperative Clinics, Catholic University of Rome, 00168 Rome, Italy
3
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
4
College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
5
Tikomed AB, 263 03 Viken, Sweden
6
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden
7
Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, Italy
8
Department of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, 95123 Catania, Italy
9
Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
10
Axolotl Consulting Ltd., Droitwich WR9 0JS, UK
*
Authors to whom correspondence should be addressed.
These Authors equally contributed to this work.
Academic Editor: Umberto Basile
J. Pers. Med. 2021, 11(8), 794; https://doi.org/10.3390/jpm11080794
Received: 23 June 2021 / Revised: 11 August 2021 / Accepted: 12 August 2021 / Published: 14 August 2021
Oxidative/nitrosative stress and mitochondrial dysfunction is a hallmark of amyotrophic lateral sclerosis (ALS), an invariably fatal progressive neurodegenerative disease. Here, as an exploratory arm of a phase II clinical trial (EudraCT Number 2017-005065-47), we used high performance liquid chromatography(HPLC) to investigate changes in the metabolic profiles of serum from ALS patients treated weekly for 4 weeks with a repeated sub-cutaneous dose of 1 mg/kg of a proprietary low molecular weight dextran sulphate, called ILB®. A significant normalization of the serum levels of several key metabolites was observed over the treatment period, including N-acetylaspartate (NAA), oxypurines, biomarkers of oxidative/nitrosative stress and antioxidants. An improved serum metabolic profile was accompanied by significant amelioration of the patients’ clinical conditions, indicating a response to ILB® treatment that appears to be mediated by improvement of tissue bioenergetics, decrease of oxidative/nitrosative stress and attenuation of (neuro)inflammatory processes. View Full-Text
Keywords: amyotrophic lateral sclerosis; low molecular weight-dextran sulphate; serum biomarkers; energy metabolism; mitochondrial dysfunction; N-acetylaspartate; amino acids; oxidative/nitrosative stress; antioxidants; HPLC amyotrophic lateral sclerosis; low molecular weight-dextran sulphate; serum biomarkers; energy metabolism; mitochondrial dysfunction; N-acetylaspartate; amino acids; oxidative/nitrosative stress; antioxidants; HPLC
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MDPI and ACS Style

Lazzarino, G.; Mangione, R.; Belli, A.; Di Pietro, V.; Nagy, Z.; Barnes, N.M.; Bruce, L.; Ropero, B.M.; Persson, L.I.; Manca, B.; Saab, M.W.; Amorini, A.M.; Tavazzi, B.; Lazzarino, G.; Logan, A. ILB® Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis. J. Pers. Med. 2021, 11, 794. https://doi.org/10.3390/jpm11080794

AMA Style

Lazzarino G, Mangione R, Belli A, Di Pietro V, Nagy Z, Barnes NM, Bruce L, Ropero BM, Persson LI, Manca B, Saab MW, Amorini AM, Tavazzi B, Lazzarino G, Logan A. ILB® Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis. Journal of Personalized Medicine. 2021; 11(8):794. https://doi.org/10.3390/jpm11080794

Chicago/Turabian Style

Lazzarino, Giacomo, Renata Mangione, Antonio Belli, Valentina Di Pietro, Zsuzsanna Nagy, Nicholas M. Barnes, Lars Bruce, Bernardo M. Ropero, Lennart I. Persson, Benedetta Manca, Miriam W. Saab, Angela M. Amorini, Barbara Tavazzi, Giuseppe Lazzarino, and Ann Logan. 2021. "ILB® Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis" Journal of Personalized Medicine 11, no. 8: 794. https://doi.org/10.3390/jpm11080794

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