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The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development

Role of microRNAs in Lung Carcinogenesis Induced by Asbestos

Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan 010008, Kazakhstan
Authors to whom correspondence should be addressed.
Academic Editor: Alessandra Pulliero
J. Pers. Med. 2021, 11(2), 97;
Received: 14 December 2020 / Revised: 25 January 2021 / Accepted: 29 January 2021 / Published: 3 February 2021
(This article belongs to the Special Issue Role of MicroRNA in Cancer Development and Treatment)
MicroRNAs are a class of small noncoding endogenous RNAs 19–25 nucleotides long, which play an important role in the post-transcriptional regulation of gene expression by targeting mRNA targets with subsequent repression of translation. MicroRNAs are involved in the pathogenesis of numerous diseases, including cancer. Lung cancer is the leading cause of cancer death in the world. Lung cancer is usually associated with tobacco smoking. However, about 25% of lung cancer cases occur in people who have never smoked. According to the International Agency for Research on Cancer, asbestos has been classified as one of the cancerogenic factors for lung cancer. The mechanism of malignant transformation under the influence of asbestos is associated with the genotoxic effect of reactive oxygen species, which initiate the processes of DNA damage in the cell. However, epigenetic mechanisms such as changes in the microRNA expression profile may also be implicated in the pathogenesis of asbestos-induced lung cancer. Numerous studies have shown that microRNAs can serve as a biomarker of the effects of various adverse environmental factors on the human body. This review examines the role of microRNAs, the expression profile of which changes upon exposure to asbestos, in key processes of carcinogenesis, such as proliferation, cell survival, metastasis, neo-angiogenesis, and immune response avoidance. View Full-Text
Keywords: carcinogenesis; lung cancer; microRNA; asbestos exposure carcinogenesis; lung cancer; microRNA; asbestos exposure
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MDPI and ACS Style

Bersimbaev, R.; Bulgakova, O.; Aripova, A.; Kussainova, A.; Ilderbayev, O. Role of microRNAs in Lung Carcinogenesis Induced by Asbestos. J. Pers. Med. 2021, 11, 97.

AMA Style

Bersimbaev R, Bulgakova O, Aripova A, Kussainova A, Ilderbayev O. Role of microRNAs in Lung Carcinogenesis Induced by Asbestos. Journal of Personalized Medicine. 2021; 11(2):97.

Chicago/Turabian Style

Bersimbaev, Rakhmetkazhy, Olga Bulgakova, Akmaral Aripova, Assiya Kussainova, and Oralbek Ilderbayev. 2021. "Role of microRNAs in Lung Carcinogenesis Induced by Asbestos" Journal of Personalized Medicine 11, no. 2: 97.

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