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Review

The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development

1
Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 20 Prague, Czech Republic
2
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine CAS, Videnska 1083, 142 20 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Alessandra Pulliero
J. Pers. Med. 2021, 11(1), 60; https://doi.org/10.3390/jpm11010060
Received: 23 December 2020 / Revised: 14 January 2021 / Accepted: 15 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Role of MicroRNA in Cancer Development and Treatment)
Small non-coding RNA molecules (miRNAs) play an important role in the epigenetic regulation of gene expression. As these molecules have been repeatedly implicated in human cancers, they have been suggested as biomarkers of the disease. Additionally, miRNA levels have been shown to be affected by environmental pollutants, including airborne contaminants. In this review, we searched the current literature for miRNAs involved in lung cancer, as well as miRNAs deregulated as a result of exposure to air pollutants. We then performed a synthesis of the data and identified those molecules commonly deregulated under both conditions. We detected a total of 25 miRNAs meeting the criteria, among them, miR-222, miR-21, miR-126-3p, miR-155 and miR-425 being the most prominent. We propose these miRNAs as biomarkers of choice for the identification of human populations exposed to air pollution with a significant risk of developing lung cancer. View Full-Text
Keywords: air pollution; biomarker; exposure; human; lung cancer; miRNA air pollution; biomarker; exposure; human; lung cancer; miRNA
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MDPI and ACS Style

Sima, M.; Rossnerova, A.; Simova, Z.; Rossner, P., Jr. The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development. J. Pers. Med. 2021, 11, 60. https://doi.org/10.3390/jpm11010060

AMA Style

Sima M, Rossnerova A, Simova Z, Rossner P Jr.. The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development. Journal of Personalized Medicine. 2021; 11(1):60. https://doi.org/10.3390/jpm11010060

Chicago/Turabian Style

Sima, Michal, Andrea Rossnerova, Zuzana Simova, and Pavel Rossner Jr. 2021. "The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development" Journal of Personalized Medicine 11, no. 1: 60. https://doi.org/10.3390/jpm11010060

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