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Review

Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review

1
Division of Prosthodontics and Implant Prosthodontics, Department of Surgical Sciences (DISC), University of Genova, 16126 Genova, Italy
2
Department of Surgical Sciences, CIR-Dental School, University of Turin, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Alessandra Pulliero and Alberto Izzotti
J. Pers. Med. 2021, 11(2), 101; https://doi.org/10.3390/jpm11020101
Received: 19 December 2020 / Revised: 29 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
(This article belongs to the Special Issue Role of MicroRNA in Cancer Development and Treatment)
Oral squamous cell carcinoma (OSCC) is a widespread malignancy with high mortality. In particular, a delay in its diagnosis dramatically decreases the survival rate. The aim of this systematic review was to investigate and summarize clinical results in the literature, regarding the potential use of salivary microRNAs (miRNAs) as diagnostic and prognostic biomarkers for OSCC patients. Twelve papers were selected, including both case–control and cohort studies, and all of them detected significantly dysregulated miRNAs in OSCC patients compared to healthy controls. Based on our results, salivary miRNAs might provide a non-invasive and cost-effective method in the diagnosis of OSCC, and also to monitor more easily its evolution and therapeutic response and therefore aid in the establishment of specific therapeutic strategies. View Full-Text
Keywords: oral squamous cell carcinoma; miRNAs; diagnosis; prognosis; saliva; biomarker oral squamous cell carcinoma; miRNAs; diagnosis; prognosis; saliva; biomarker
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MDPI and ACS Style

Menini, M.; De Giovanni, E.; Bagnasco, F.; Delucchi, F.; Pera, F.; Baldi, D.; Pesce, P. Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review. J. Pers. Med. 2021, 11, 101. https://doi.org/10.3390/jpm11020101

AMA Style

Menini M, De Giovanni E, Bagnasco F, Delucchi F, Pera F, Baldi D, Pesce P. Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review. Journal of Personalized Medicine. 2021; 11(2):101. https://doi.org/10.3390/jpm11020101

Chicago/Turabian Style

Menini, Maria, Emanuele De Giovanni, Francesco Bagnasco, Francesca Delucchi, Francesco Pera, Domenico Baldi, and Paolo Pesce. 2021. "Salivary Micro-RNA and Oral Squamous Cell Carcinoma: A Systematic Review" Journal of Personalized Medicine 11, no. 2: 101. https://doi.org/10.3390/jpm11020101

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