Next Article in Journal
Role of microRNAs in Lung Carcinogenesis Induced by Asbestos
Previous Article in Journal
Women’s Views on Multifactorial Breast Cancer Risk Assessment and Risk-Stratified Screening: A Population-Based Survey from Four Provinces in Canada
Perspective

Prognosis-Based Early Intervention Strategies to Resolve Exacerbation and Progressive Lung Function Decline in Cystic Fibrosis

by 1,2,3
1
Precision Theranostics Inc., Baltimore, MD 21202, USA
2
VIJ Biotech, Baltimore, MD 21202, USA
3
Department of Pediatrics & Pulmonary Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Academic Editor: Kentaro Inamura
J. Pers. Med. 2021, 11(2), 96; https://doi.org/10.3390/jpm11020096
Received: 11 January 2021 / Revised: 29 January 2021 / Accepted: 29 January 2021 / Published: 3 February 2021
Cystic fibrosis (CF) is a genetic disease caused by a mutation(s) in the CF transmembrane regulator (CFTR), where progressive decline in lung function due to recurring exacerbations is a major cause of mortality. The initiation of chronic obstructive lung disease in CF involves inflammation and exacerbations, leading to mucus obstruction and lung function decline. Even though clinical management of CF lung disease has prolonged survival, exacerbation and age-related lung function decline remain a challenge for controlling the progressive lung disease. The key to the resolution of progressive lung disease is prognosis-based early therapeutic intervention; thus, the development of novel diagnostics and prognostic biomarkers for predicting exacerbation and lung function decline will allow optimal management of the lung disease. Hence, the development of real-time lung function diagnostics such as forced oscillation technique (FOT), impulse oscillometry system (IOS), and electrical impedance tomography (EIT), and novel prognosis-based intervention strategies for controlling the progression of chronic obstructive lung disease will fulfill a significant unmet need for CF patients. Early detection of CF lung inflammation and exacerbations with the timely resolution will not only prolong survival and reduce mortality but also improve quality of life while reducing significant health care costs due to recurring hospitalizations. View Full-Text
Keywords: CFTR; cystic fibrosis; prognosis; lung; precision medicine; airway; therapeutics; COPD; asthma; obstructive lung diseases; exacerbation CFTR; cystic fibrosis; prognosis; lung; precision medicine; airway; therapeutics; COPD; asthma; obstructive lung diseases; exacerbation
Show Figures

Figure 1

MDPI and ACS Style

Vij, N. Prognosis-Based Early Intervention Strategies to Resolve Exacerbation and Progressive Lung Function Decline in Cystic Fibrosis. J. Pers. Med. 2021, 11, 96. https://doi.org/10.3390/jpm11020096

AMA Style

Vij N. Prognosis-Based Early Intervention Strategies to Resolve Exacerbation and Progressive Lung Function Decline in Cystic Fibrosis. Journal of Personalized Medicine. 2021; 11(2):96. https://doi.org/10.3390/jpm11020096

Chicago/Turabian Style

Vij, Neeraj. 2021. "Prognosis-Based Early Intervention Strategies to Resolve Exacerbation and Progressive Lung Function Decline in Cystic Fibrosis" Journal of Personalized Medicine 11, no. 2: 96. https://doi.org/10.3390/jpm11020096

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop