Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Statistical Analysis
4. Results
5. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N0 | N1 | N2a | N2b | N2c | |
---|---|---|---|---|---|
T1 | 8 | ||||
T2 | 40 | 4 | 5 | 1 | 1 |
T3 | 27 | 7 | 3 | 6 | 1 |
T4 | 3 | 1 | 1 |
N0 | N1 | N2a | N2b | N2c | |
---|---|---|---|---|---|
G1 | 1 | ||||
G2 | 29 | 3 | 4 | 1 | |
G3 | 48 | 9 | 5 | 6 | 2 |
Factor | Estimate | 95% Confident Interval |
---|---|---|
InterceptNLR | −5.76 | −8.63; −2.89 |
βNLR | 1.95 | 0.85; 3.04 |
Coefficients | p Value | p Value at Kruskal–Wallis Test | |
---|---|---|---|
Intercept | −0.27 | 0.30 | 0.01 |
NLR | 0.05 | 0.04 | |
PLR | 0.00 | 0.93 | |
T stage | 0.14 | 0.02 | |
Grading | 0.01 | 0.90 | |
Perineural invasion | 0.14 | 0.19 | |
Lymphovascular invasion | −0.09 | 0.31 |
NRL Linear Regression Model | Coefficients | p Value | AUC | Accuracy | Sensitivity | Specificity | PPV | NPV | Cut-Off |
---|---|---|---|---|---|---|---|---|---|
Intercept | 0.06 | 0.482 | 0.67 | 0.60 | 0.76 | 0.49 | 0.83 | 0.71 | 0.27 |
NRL | 0.07 | 0.002 | |||||||
PLR Linear Regression Model | Coefficients | p value | AUC | Accuracy | Sensitivity | Specificity | PPV | NPV | Cut-off |
Intercept | 153.58 | 2.4 × 10−20 | 0.61 | 0.70 | 0.54 | 0.37 | 0.82 | 0.58 | 4378.12 |
PLR | 34.22 | 0.18 | |||||||
Linear regression model of all clinico-pathologic variables | 0.73 | 0.80 | 0.64 | 0.46 | 0.89 | 0.69 | 0.26 |
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Salzano, G.; Perri, F.; Maglitto, F.; Togo, G.; De Fazio, G.R.; Apolito, M.; Calabria, F.; Laface, C.; Vaira, L.A.; Committeri, U.; et al. Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer. J. Pers. Med. 2021, 11, 1252. https://doi.org/10.3390/jpm11121252
Salzano G, Perri F, Maglitto F, Togo G, De Fazio GR, Apolito M, Calabria F, Laface C, Vaira LA, Committeri U, et al. Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer. Journal of Personalized Medicine. 2021; 11(12):1252. https://doi.org/10.3390/jpm11121252
Chicago/Turabian StyleSalzano, Giovanni, Francesco Perri, Fabio Maglitto, Giulia Togo, Gianluca Renato De Fazio, Michela Apolito, Federica Calabria, Claudia Laface, Luigi Angelo Vaira, Umberto Committeri, and et al. 2021. "Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer" Journal of Personalized Medicine 11, no. 12: 1252. https://doi.org/10.3390/jpm11121252