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Lower CSF Amyloid-Beta1–42 Predicts a Higher Mortality Rate in Frontotemporal Dementia

1
Neurology Department, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal
2
Faculty of Medicine, University of Coimbra, 3000-070 Coimbra, Portugal
3
Center for Neuroscience and Cell Biology, University of Coimbra, 3000-070 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Diagnostics 2019, 9(4), 162; https://doi.org/10.3390/diagnostics9040162
Received: 30 September 2019 / Revised: 22 October 2019 / Accepted: 22 October 2019 / Published: 25 October 2019
(This article belongs to the Special Issue Diagnosis of Dementia and Cognitive Impairment)
Frontotemporal lobar degeneration, the neuropathological substrate of frontotemporal dementia (FTD), is characterized by the deposition of protein aggregates, including tau. Evidence has shown concomitant amyloid pathology in some of these patients, which seems to contribute to a more aggressive disease. Our aim was to evaluate cerebrospinal fluid (CSF) amyloid-beta as a predictor of the mortality of FTD patients. We included 99 patients diagnosed with FTD—both behavioral and language variants—with no associated motor neuron disease, from whom a CSF sample was collected. These patients were followed prospectively in our center, and demographic and clinical data were obtained. The survival analysis was carried through a Cox regression model. Patients who died during follow up had a significantly lower CSF amyloid-beta1–42 than those who did not. The survival analysis demonstrated that an increased death rate was associated with a lower CSF amyloid-beta1–42 (HR = 0.999, 95% CI = [0.997, 1.000], p = 0.049). Neither demographic nor clinical variables, nor CSF total tau or p-tau were significantly associated with this endpoint. These results suggest that amyloid deposition in FTD patients may be associated with a higher mortality. View Full-Text
Keywords: frontotemporal dementia; amyloid; cerebrospinal fluid; mortality frontotemporal dementia; amyloid; cerebrospinal fluid; mortality
MDPI and ACS Style

Vieira, D.; Durães, J.; Baldeiras, I.; Santiago, B.; Duro, D.; Lima, M.; Leitão, M.J.; Tábuas-Pereira, M.; Santana, I. Lower CSF Amyloid-Beta1–42 Predicts a Higher Mortality Rate in Frontotemporal Dementia. Diagnostics 2019, 9, 162.

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