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Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents

1
Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, P.O. Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
2
Division of Periodontology, Department of Dental Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden
3
Institute for Molecular Diagnostics (IMOD), Bonner Str. 84, 42697 Solingen, Germany
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(1), 34; https://doi.org/10.3390/diagnostics9010034
Received: 26 February 2019 / Revised: 16 March 2019 / Accepted: 21 March 2019 / Published: 23 March 2019
(This article belongs to the Special Issue New Era of Testing: Salivary Diagnostics)
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Abstract

This cross-sectional study compares the effectiveness of an active MMP-8 (aMMP-8) point-of-care (PoC)/chairside mouthrinse test to the conventional bleeding on probing (BOP) (cutoff 20%) test in detecting subclinical periodontitis/pre-periodontitis in Finnish adolescents. The study was carried out at the Kotka Health Center, Finland. A total of 47 adolescents (30 boys/17 girls) aged 15–17 were first tested with the aMMP-8 PoC test, followed by a full-mouth evaluation of clinical parameters of oral health including periodontal, oral mucosal, and caries assessment. A periodontist performed these clinical examinations. The aMMP-8 PoC test result had much stronger association with subclinical periodontitis than the BOP 20% test (2.8–5.3 times stronger in terms of odds ratio). The aMMP-8 PoC test had ≥2 times higher sensitivity than the BOP 20% test with, generally, the same specificity. Further, the aMMP-8 PoC test had generally better accuracy and lower false negative percentages. The aMMP-8 PoC test seemed to be more effective than the conventional BOP test in detecting subclinical periodontitis/pre-periodontitis in adolescents reducing the risk of their undertreatment. However, the sample size may be a limiting factor, and more studies are needed to confirm our results for both adolescents and adults. View Full-Text
Keywords: adolescent; periodontitis; matrix metalloproteinases; point-of-care testing; gingival bleeding on probing adolescent; periodontitis; matrix metalloproteinases; point-of-care testing; gingival bleeding on probing
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Räisänen, I.T.; Sorsa, T.; van der Schoor, G.-J.; Tervahartiala, T.; van der Schoor, P.; Gieselmann, D.-R.; Heikkinen, A.M. Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents. Diagnostics 2019, 9, 34.

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