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Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective

Division of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, Montreal, QC H3T 1C5, Canada
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Diagnostics 2013, 3(1), 1-12; https://doi.org/10.3390/diagnostics3010001
Received: 5 December 2012 / Revised: 20 December 2012 / Accepted: 31 December 2012 / Published: 10 January 2013
(This article belongs to the Collection Feature Papers)
Making a diagnosis of Kawasaki disease with certainty may be challenging, especially since the recognition of cases with incomplete diagnostic criteria and its consequences. In order to build the diagnostic case in daily practice, clinicians rely on clinical criteria established over four decades ago, aided by non specific laboratory tests, and above all inspired by experience. We have recently studied the diagnostic value of N-terminal pro B-type natriuretic peptide to improve the diagnostic certainty of cases with complete or incomplete clinical criteria. Our working hypothesis was based on the fact that myocarditis is present in nearly all Kawasaki disease patients supported by histology data. In this paper, we review these facts and the myocardial perspective from the diagnostic and the mechanistic standpoints. View Full-Text
Keywords: Kawasaki disease; myocarditis; NT-proBNP; hyponatremia; diagnosis; prognosis Kawasaki disease; myocarditis; NT-proBNP; hyponatremia; diagnosis; prognosis
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Dahdah, N.; Fournier, A. Natriuretic Peptides in Kawasaki Disease: the Myocardial Perspective. Diagnostics 2013, 3, 1-12.

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