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Volume 15
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10.3390/diagnostics15050609
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Article

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II

by
Ionut Catalin Botezatu
1,
Maria-Alexandra Martu
2,*,
Laura Stoica
1,
Ana Emanuela Botez
1,
Pavel Onofrei
1,
Cristina Daniela Dimitriu
3,
Bogdan Vasile Grecu
1,
Ionut Daniel Gafincu Grigoriu
1,
Oana Ciurcanu
4,
Carmen Solcan
5,
Anca Ileana Sin
1 and
Elena-Carmen Cotrutz
1
1
Department of Cell and Molecular Biology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
2
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
3
Department of Biochemistry, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
4
Department of Dento-Alveolar Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
5
Department of Cell and Molecular Biology, University of Agricultural Science and Veterinary Medicine “Ion Ionescu de la Brad”, 700490 Iași, Romania
*
Author to whom correspondence should be addressed.
Diagnostics 2025, 15(5), 609; https://doi.org/10.3390/diagnostics15050609
Submission received: 18 January 2025 / Revised: 13 February 2025 / Accepted: 28 February 2025 / Published: 3 March 2025
(This article belongs to the Special Issue Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology)
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Abstract

Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates the severity of periodontal conditions. Matrix metalloproteinases (MMPs) are known to degrade periodontal ligament attachment and bone matrix proteins. Increased expression of CD147 is associated with increased synthesis of several MMPs, being a modulator of MMP expression, including that of MMP-14. The purpose of this study was to quantify and compare the expressions of MMP-14 and CD147 in gingival tissues of patients with and without type 2 diabetes mellitus. Material and Methods: In this histological study, we included 33 subjects with periodontal disease: 16 patients with type 2 DM (test group) and 17 systemically healthy patients (control group). Tissue fragments were processed using an immunohistochemistry technique to determine immunoreactivity (IR) intensity of MMP-14 and CD147. Results: In the group of diabetes patients with periodontitis, 56.2% showed weak positive expressions (+), while 43.8% had intensely positive expressions (+++) of MMP-14. Statistically significant differences between test and control groups (p = 0.004, p = 0.883, and p = 0.002) were found for the membranous IR intensity of MMP-14. In the group of diabetes patients with periodontitis, 56.2% had moderate positive expressions (++) of CD 147, while 43.8% showed intensely positive expressions (+++). Statistically significant differences between the test and control groups were found (p = 0.001, p = 0.002, and p = 0.003) for the membranous IR intensity of CD147. Conclusions: The significantly higher membranous IR intensity for MMP-14 and CD 147 demonstrates the role of these biomarkers in the development of periodontal pathology in diabetes patients. It can be assumed that MMP-14 and CD147 could be further investigated as potential predictive biomarkers.
Keywords: periodontal disease; diabetes mellitus type 2; EMMPRIN; CD147; MMP-14 periodontal disease; diabetes mellitus type 2; EMMPRIN; CD147; MMP-14

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MDPI and ACS Style

Botezatu, I.C.; Martu, M.-A.; Stoica, L.; Botez, A.E.; Onofrei, P.; Dimitriu, C.D.; Grecu, B.V.; Grigoriu, I.D.G.; Ciurcanu, O.; Solcan, C.; et al. Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II. Diagnostics 2025, 15, 609. https://doi.org/10.3390/diagnostics15050609

AMA Style

Botezatu IC, Martu M-A, Stoica L, Botez AE, Onofrei P, Dimitriu CD, Grecu BV, Grigoriu IDG, Ciurcanu O, Solcan C, et al. Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II. Diagnostics. 2025; 15(5):609. https://doi.org/10.3390/diagnostics15050609

Chicago/Turabian Style

Botezatu, Ionut Catalin, Maria-Alexandra Martu, Laura Stoica, Ana Emanuela Botez, Pavel Onofrei, Cristina Daniela Dimitriu, Bogdan Vasile Grecu, Ionut Daniel Gafincu Grigoriu, Oana Ciurcanu, Carmen Solcan, and et al. 2025. "Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II" Diagnostics 15, no. 5: 609. https://doi.org/10.3390/diagnostics15050609

APA Style

Botezatu, I. C., Martu, M.-A., Stoica, L., Botez, A. E., Onofrei, P., Dimitriu, C. D., Grecu, B. V., Grigoriu, I. D. G., Ciurcanu, O., Solcan, C., Sin, A. I., & Cotrutz, E.-C. (2025). Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II. Diagnostics, 15(5), 609. https://doi.org/10.3390/diagnostics15050609

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