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Review
Peer-Review Record

Autoimmune Encephalitis with Antibodies: Anti-NMDAR, Anti-AMPAR, Anti-GQ1b, Anti-DPPX, Anti-CASPR2, Anti-LGI1, Anti-RI, Anti-Yo, Anti-Hu, Anti-CV2 and Anti-GABAAR, in the Course of Psychoses, Neoplastic Diseases, and Paraneoplastic Syndromes

Diagnostics 2023, 13(15), 2589; https://doi.org/10.3390/diagnostics13152589
by Michał Braczkowski 1,*, Dariusz Soszyński 1,2, Alicja Sierakowska 3,4, Ryszard Braczkowski 5, Klaudia Kufel 3 and Beata Łabuz-Roszak 6,7
Reviewer 1: Anonymous
Reviewer 2:
Diagnostics 2023, 13(15), 2589; https://doi.org/10.3390/diagnostics13152589
Submission received: 25 May 2023 / Revised: 25 July 2023 / Accepted: 2 August 2023 / Published: 3 August 2023
(This article belongs to the Special Issue Diagnostics in Immunological, Allergic and Inflammatory Disorders)

Round 1

Reviewer 1 Report

The paper presented to me for review is a review article on autoimmune encephalitis with selected antibodies in the course of psychoses, neoplastic diseases and paraneoplastic syndromes. The paper is written quite well and exhausts the topic sufficiently.

However, before accepting the paper for publication, I would suggest some corrections and additions that could enhance its value: 

1. there is a missing chapter on the search strategy and methodology on how the authors selected the articles in question, from what database and quantity they chose, what they rejected 

2. the work would benefit from clarity if the authors included some of the information in tables or diagrams. it is usually very difficult to get information from continuous text and the reader quickly becomes discouraged

3. in the discussion, it is worth mentioning the most likely underdiagnosed disease entity of Hashimoto's encephalopathy, in which the antibodies mentioned by the authors may be present on the basis of: PMCID: PMC9496753

Author Response

in response

ad 1 "there is a missing chapter on the search strategy and methodology on how the authors selected the articles in question, from what database and quantity they chose, what they rejected" we added subsection with the title strategy and methodology;

ad 2 "the work would benefit from clarity if the authors included some of the information in tables or diagrams. it is usually very difficult to get information from continuous text and the reader quickly becomes discouraged" we added diagram "distribution of antigen in cellular" and graph "incidence of particular antibodies";

ad 3 "in the discussion, it is worth mentioning the most likely underdiagnosed disease entity of Hashimoto's encephalopathy, in which the antibodies mentioned by the authors may be present on the basis of: PMCID: PMC9496753" Chapter 4 has been expanded to include information on EH in the aspect of  autoimmune encephalitis antibodies. 

 

Author Response File: Author Response.pdf

Reviewer 2 Report

Although this review article foucses on the high-frequency antibodies in autoimmune encephalitis, I would suggest a full list of autoimmune encephalitis-associated antibodies presenting in this review.

English language polishing may be benificial to this review article.

Author Response

Ad "Although this review article foucses on the high-frequency antibodies in autoimmune encephalitis, I would suggest a full list of autoimmune encephalitis-associated antibodies presenting in this review"  In the title as well as the text, all antibodies associated with autoimmune encephalitis are listed

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

The authors fully addressed my suggestions and included everything in the manuscript. The paper is ready for publication. 

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