Alternate Antimicrobial Therapies and Their Companion Tests

Round 1

Reviewer 1 Report

The authors provided an extensive up-to-date review of alternative antimicrobial treatment and diagnostics. The manuscript will interest a wide audience of physicians, researchers, and health providers. Overall, great and needful article.

Reviewer 2 Report

Dear authors,

This subject still arouses the interest of professionals in the medical field. I congratulate you for the work you have done and for the chosen subject.

The article is an exhaustive description of the current situation in antibiotic therapy. Personalized medicine in infectious diseases is an emerging concept that involves rapid, accurate and comprehensive diagnosis. Comparative genomics using bioinformatics and microarray technology may be the future for infectious disease therapy.

Diagnostic stewardship is an interesting concept in modern medicine.

I appreciated the attention given to the CDx Test, an imperative decision tool for a pharmacotherapeutic intervention today. CDx is important in both drug development and individualized treatment, as you explained.

Antibiotic and antifungal resistance is a major problem in modern medicine. Attention is shifting to alternative antimicrobial therapies, such as monoclonal antibodies, antimicrobial peptides, aptamers and phage therapy.

Phage therapy is a potential alternative to antibiotic therapy, and its revival has been supported by many theoretical opinions, especially in the last 5 years when we are faced with more and more polyantibiotic resistance.

Despite the fact that the article is written in a language less accessible to the general medical public, the problem is the one that arouses interest. In the end, the benefit is in understanding the new proposed therapies, because the future will be in this sense.

Thanks to the authors for this development of the topic related to antimicrobial resistance.