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Review

Influence of S100A2 in Human Diseases

Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
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Author to whom correspondence should be addressed.
Diagnostics 2022, 12(7), 1756; https://doi.org/10.3390/diagnostics12071756
Submission received: 7 June 2022 / Revised: 13 July 2022 / Accepted: 19 July 2022 / Published: 20 July 2022
(This article belongs to the Section Pathology and Molecular Diagnostics)

Abstract

S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain. The S100 family of proteins is distributed across various organs and can interact with diverse molecules. Among the proteins of the S100 family, S100 calcium-binding protein A2 (S100A2) has been identified in mammary epithelial cells, glands, lungs, kidneys, and prostate gland, exhibiting various physiological and pathological actions in human disorders, such as inflammatory diseases and malignant tumors. In this review, we introduce basic knowledge regarding S100A2 regulatory mechanisms. Although S100A2 is a tumor suppressor, we describe the various influences of S100A2 on cancer and inflammatory diseases.
Keywords: S100A2; cancers; inflammatory diseases S100A2; cancers; inflammatory diseases

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MDPI and ACS Style

Sugino, H.; Sawada, Y. Influence of S100A2 in Human Diseases. Diagnostics 2022, 12, 1756. https://doi.org/10.3390/diagnostics12071756

AMA Style

Sugino H, Sawada Y. Influence of S100A2 in Human Diseases. Diagnostics. 2022; 12(7):1756. https://doi.org/10.3390/diagnostics12071756

Chicago/Turabian Style

Sugino, Hitomi, and Yu Sawada. 2022. "Influence of S100A2 in Human Diseases" Diagnostics 12, no. 7: 1756. https://doi.org/10.3390/diagnostics12071756

APA Style

Sugino, H., & Sawada, Y. (2022). Influence of S100A2 in Human Diseases. Diagnostics, 12(7), 1756. https://doi.org/10.3390/diagnostics12071756

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