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Volume 12
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Review

Bicuspid Aortic Valve in Children and Adolescents: A Comprehensive Review

by
Gaia Spaziani
1,*,
Francesca Girolami
1,
Luigi Arcieri
2,
Giovanni Battista Calabri
1,
Giulio Porcedda
1,
Chiara Di Filippo
1,
Francesca Chiara Surace
2,
Marco Pozzi
2 and
Silvia Favilli
1
1
Pediatric and Transition Cardiology, Meyer Children’s Hospital, Viale Pieraccini 24, 50139 Florence, Italy
2
Pediatric Cardiology and Cardiac Surgery, Ospedali Riuniti, Via Conca 71, 60126 Ancona, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(7), 1751; https://doi.org/10.3390/diagnostics12071751
Submission received: 18 May 2022 / Revised: 12 July 2022 / Accepted: 19 July 2022 / Published: 20 July 2022
(This article belongs to the Special Issue Thoracic Aortic Disease: From Bench to Bedside)
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Abstract

Bicuspid aortic valve (BAV) is the most common congenital heart defect. Prevalence of isolated BAV in the general pediatric population is about 0.8%, but it has been reported to be as high as 85% in patients with aortic coarctation. A genetic basis has been recognized, with great heterogeneity. Standard BAV terminology, recently proposed on the basis of morpho-functional assessment by transthoracic echocardiography, may be applied also to the pediatric population. Apart from neonatal stenotic BAV, progression of valve dysfunction and/or of the associated aortic dilation seems to be slow during pediatric age and complications are reported to be much rarer in comparison with adults. When required, because of severe BAV dysfunction, surgery is most often the therapeutic choice; however, the ideal initial approach to treat severe aortic stenosis in children or adolescents is not completely defined yet, and a percutaneous approach may be considered in selected cases as a palliative option in order to postpone surgery. A comprehensive and tailored evaluation is needed to define the right intervals for cardiologic evaluation, indications for sport activity and the right timing for intervention.
Keywords: bicuspid aortic valve; children; diagnostic imaging; echocardiography; natural history bicuspid aortic valve; children; diagnostic imaging; echocardiography; natural history

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MDPI and ACS Style

Spaziani, G.; Girolami, F.; Arcieri, L.; Calabri, G.B.; Porcedda, G.; Di Filippo, C.; Surace, F.C.; Pozzi, M.; Favilli, S. Bicuspid Aortic Valve in Children and Adolescents: A Comprehensive Review. Diagnostics 2022, 12, 1751. https://doi.org/10.3390/diagnostics12071751

AMA Style

Spaziani G, Girolami F, Arcieri L, Calabri GB, Porcedda G, Di Filippo C, Surace FC, Pozzi M, Favilli S. Bicuspid Aortic Valve in Children and Adolescents: A Comprehensive Review. Diagnostics. 2022; 12(7):1751. https://doi.org/10.3390/diagnostics12071751

Chicago/Turabian Style

Spaziani, Gaia, Francesca Girolami, Luigi Arcieri, Giovanni Battista Calabri, Giulio Porcedda, Chiara Di Filippo, Francesca Chiara Surace, Marco Pozzi, and Silvia Favilli. 2022. "Bicuspid Aortic Valve in Children and Adolescents: A Comprehensive Review" Diagnostics 12, no. 7: 1751. https://doi.org/10.3390/diagnostics12071751

APA Style

Spaziani, G., Girolami, F., Arcieri, L., Calabri, G. B., Porcedda, G., Di Filippo, C., Surace, F. C., Pozzi, M., & Favilli, S. (2022). Bicuspid Aortic Valve in Children and Adolescents: A Comprehensive Review. Diagnostics, 12(7), 1751. https://doi.org/10.3390/diagnostics12071751

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