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Article

Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee

by
Frank Sebastian Fröschen
1,*,
Thomas Martin Randau
1,
Alexander Franz
1,
Ernst Molitor
2 and
Gunnar Thorben Rembert Hischebeth
2
1
Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany
2
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(7), 1654; https://doi.org/10.3390/diagnostics12071654
Submission received: 22 May 2022 / Revised: 26 June 2022 / Accepted: 6 July 2022 / Published: 7 July 2022
(This article belongs to the Special Issue Diagnosis and Treatment of Periprosthetic Joint Infections)
Versions Notes

Abstract

Periprosthetic joint infections (PJI) are one of the most devastating consequences after total joint arthroplasty. We sought to analyze the causative pathogens of patients with PJI to get better insights and improve treatment. We performed a retrospective study of all patients with PJI of the hip and knee with microbiological detection of a causative pathogen at a tertiary endoprothetic referral center between January 2016 and March 2021. A total of 432 cases with PJI (hip: n = 250; knee: n = 182) were included. The most common causative pathogen were coagulase-negative staphylococci (n = 240; 44.2%), of which Staphylococcus epidermidis (n = 144; 26.7%) was the most frequently detected, followed by S. aureus (n = 77; 14.3%) and enterococci (n = 49; 9%). Gram-negative pathogens and fungi could be detected in 21% (n = 136) and 2.4% (n = 13) of all cases. Overall, 60% of all coagulase-negative staphylococci were oxacillin-resistant, while none of these displayed to be vancomycin-resistant. In summary, the majority of pathogens in cases of PJI could be identified as coagulase-negative staphylococci. For empirical therapy vancomycin might provide the highest antimicrobial coverage in case of an unknown pathogen.
Keywords: hip; knee; periprosthetic joint infection; antimicrobial resistance; microorganism hip; knee; periprosthetic joint infection; antimicrobial resistance; microorganism

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MDPI and ACS Style

Fröschen, F.S.; Randau, T.M.; Franz, A.; Molitor, E.; Hischebeth, G.T.R. Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee. Diagnostics 2022, 12, 1654. https://doi.org/10.3390/diagnostics12071654

AMA Style

Fröschen FS, Randau TM, Franz A, Molitor E, Hischebeth GTR. Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee. Diagnostics. 2022; 12(7):1654. https://doi.org/10.3390/diagnostics12071654

Chicago/Turabian Style

Fröschen, Frank Sebastian, Thomas Martin Randau, Alexander Franz, Ernst Molitor, and Gunnar Thorben Rembert Hischebeth. 2022. "Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee" Diagnostics 12, no. 7: 1654. https://doi.org/10.3390/diagnostics12071654

APA Style

Fröschen, F. S., Randau, T. M., Franz, A., Molitor, E., & Hischebeth, G. T. R. (2022). Microbiological Profiles of Patients with Periprosthetic Joint Infection of the Hip or Knee. Diagnostics, 12(7), 1654. https://doi.org/10.3390/diagnostics12071654

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