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10.3390/diagnostics12040797
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Article

Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids

by
Brian C. DeFelice
1,
Oliver Fiehn
1,
Peter Belafsky
2,
Constanze Ditterich
2,
Michael Moore
2,
Marianne Abouyared
2,
Angela M. Beliveau
2,
D. Gregory Farwell
2,
Arnaud F. Bewley
2,
Shannon M. Clayton
2,
Joehleen A. Archard
2,
Jordan Pavlic
2,
Shyam Rao
3,
Maggie Kuhn
2,
Peter Deng
4,
Julian Halmai
4,
Kyle D. Fink
4,
Andrew C. Birkeland
2,* and
Johnathon D. Anderson
2,*
1
West Coast Metabolomics Center, University of California, Davis, CA 95616, USA
2
Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA
3
Department of Radiation Oncology, University of California, Davis, CA 95616, USA
4
Department of Neurology, University of California, Davis, CA 95616, USA
*
Authors to whom correspondence should be addressed.
Diagnostics 2022, 12(4), 797; https://doi.org/10.3390/diagnostics12040797
Submission received: 30 January 2022 / Revised: 9 March 2022 / Accepted: 14 March 2022 / Published: 24 March 2022
(This article belongs to the Special Issue Advances in Diagnostics of Head and Neck Cancer)
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Abstract

Background: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to assess the concentration of polyamines in the saliva and urine from head and neck cancer (HNC) patients, compared to healthy controls. Methods: Targeted metabolomic analysis was performed on saliva and urine from 39 HNC patient samples and compared to 89 healthy controls using a quantitative, targeted liquid chromatography mass spectrometry approach. Results: The metabolites N1-acetylspermine (ASP), N8-acetylspermidine (ASD) and N1,N12-diacetylspermine (DAS) were detected at significantly different concentrations in the urine of HNC patients as compared to healthy controls. Only ASP was detected at elevated levels in HNC saliva as compared to healthy controls. Conclusion: These data suggest that assessment of polyamine-based metabolite biomarkers within the saliva and urine warrants further investigation as a potential diagnostic in HNC patients.
Keywords: head and neck cancer; biomarkers; metabolomics; polyamines; saliva; urine head and neck cancer; biomarkers; metabolomics; polyamines; saliva; urine

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MDPI and ACS Style

DeFelice, B.C.; Fiehn, O.; Belafsky, P.; Ditterich, C.; Moore, M.; Abouyared, M.; Beliveau, A.M.; Farwell, D.G.; Bewley, A.F.; Clayton, S.M.; et al. Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids. Diagnostics 2022, 12, 797. https://doi.org/10.3390/diagnostics12040797

AMA Style

DeFelice BC, Fiehn O, Belafsky P, Ditterich C, Moore M, Abouyared M, Beliveau AM, Farwell DG, Bewley AF, Clayton SM, et al. Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids. Diagnostics. 2022; 12(4):797. https://doi.org/10.3390/diagnostics12040797

Chicago/Turabian Style

DeFelice, Brian C., Oliver Fiehn, Peter Belafsky, Constanze Ditterich, Michael Moore, Marianne Abouyared, Angela M. Beliveau, D. Gregory Farwell, Arnaud F. Bewley, Shannon M. Clayton, and et al. 2022. "Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids" Diagnostics 12, no. 4: 797. https://doi.org/10.3390/diagnostics12040797

APA Style

DeFelice, B. C., Fiehn, O., Belafsky, P., Ditterich, C., Moore, M., Abouyared, M., Beliveau, A. M., Farwell, D. G., Bewley, A. F., Clayton, S. M., Archard, J. A., Pavlic, J., Rao, S., Kuhn, M., Deng, P., Halmai, J., Fink, K. D., Birkeland, A. C., & Anderson, J. D. (2022). Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids. Diagnostics, 12(4), 797. https://doi.org/10.3390/diagnostics12040797

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