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Article

4D Doppler Ultrasound in High Grade Serous Ovarian Cancer Vascularity Evaluation—Preliminary Study

1
Department of Perinatology and Oncological Gynecology, Faculty of Medical Sciences, Medical University of Silesia, Medyków 14, 40-752 Katowice, Poland
2
Department of Gynecology and Obstetrics, Charles University—First Faculty of Medicine and Bulovka University Hospital, Budinova 67/2, 181 00 Prague, Czech Republic
3
Gynecologic Oncology Centre, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University, General University Hospital, Apolinarska 18, 12851 Prague, Czech Republic
4
Department of Gynecology, Obstetrics and Oncological Gynecology, Faculty of Medical Sciences, Medical University of Silesia, Batorego 15, 41-902 Bytom, Poland
5
Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, University of Navarra, Avenida Pio XII, 36, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Artur Czekierdowski
Diagnostics 2021, 11(4), 582; https://doi.org/10.3390/diagnostics11040582
Received: 4 January 2021 / Revised: 8 March 2021 / Accepted: 15 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Gynecological Tumor Imaging)
The aim of the study was to evaluate the usefulness of 4D Power Doppler tissue evaluation to discriminate between normal ovaries and ovarian cancer tumors. This was a prospective observational study. Twenty-three cases of surgically confirmed ovarian High Grade Serous Carcinoma (HGSC) were analyzed. The control group consisted of 23 healthy patients, each matching their study-group counterpart age wise (±3 years) and according to their menopausal status. Transvaginal Doppler 4D ultrasound scans were done on every patient and analyzed with 3D/4D software. Two 4D indices—volumetric Systolic/Diastolic Index (vS/D) and volumetric Pulsatility Index (vPI)—were calculated. To keep results standardized and due to technical limitations, virtual 1cc spherical tissue samples taken from the part with highest vascularization as detected by bi-directional Power Doppler were analyzed for both groups of ovaries. Values of volumetric S/D indices and volumetric PI indices were statistically lower in ovarian malignant tumors compared to normal ovaries: 1.096 vs. 1.794 and 0.092 vs. 0.558, respectively (p < 0.001). The 4D bi-directional Power Doppler vascular indices were statistically different between malignant tumors and normal ovaries. These findings could support the rationale for future studies for assessing this technology to discriminate between malignant and benign tumors. View Full-Text
Keywords: 4D ultrasound; Doppler; STIC; ovary; cancer 4D ultrasound; Doppler; STIC; ovary; cancer
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MDPI and ACS Style

Kudla, M.J.; Zikan, M.; Fischerova, D.; Stolecki, M.; Alcazar, J.L. 4D Doppler Ultrasound in High Grade Serous Ovarian Cancer Vascularity Evaluation—Preliminary Study. Diagnostics 2021, 11, 582. https://doi.org/10.3390/diagnostics11040582

AMA Style

Kudla MJ, Zikan M, Fischerova D, Stolecki M, Alcazar JL. 4D Doppler Ultrasound in High Grade Serous Ovarian Cancer Vascularity Evaluation—Preliminary Study. Diagnostics. 2021; 11(4):582. https://doi.org/10.3390/diagnostics11040582

Chicago/Turabian Style

Kudla, Marek J., Michal Zikan, Daniela Fischerova, Mateusz Stolecki, and Juan L. Alcazar. 2021. "4D Doppler Ultrasound in High Grade Serous Ovarian Cancer Vascularity Evaluation—Preliminary Study" Diagnostics 11, no. 4: 582. https://doi.org/10.3390/diagnostics11040582

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