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Article

Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study

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Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy
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Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
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Obstetrics-Gynecological Ultrasound and Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, City of Health and Science, 10126 Turin, Italy
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Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy
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Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL ‘Città di Torino’, 10126 Turin, Italy
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Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Bettina Blaumeiser
Diagnostics 2021, 11(3), 398; https://doi.org/10.3390/diagnostics11030398
Received: 29 December 2020 / Revised: 19 February 2021 / Accepted: 22 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Diagnosis and Management in Prenatal Medicine)
This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (p = 0.77, 0.63, 0.30, 0.40, 0.28) or in the fetal incidence of structural anomalies at the second-trimester fetal anatomy scan (p = 0.21). No pneumonia or hospital admission due to COVID-19-related symptoms were observed. Asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women. COVID-19 had a favorable maternal course at the beginning of pregnancy in our healthy cohort. View Full-Text
Keywords: COVID-19; fetal congenital anomalies; fetus; first trimester; nuchal translucency; prenatal screening test; SARS-CoV-2; vertical transmission COVID-19; fetal congenital anomalies; fetus; first trimester; nuchal translucency; prenatal screening test; SARS-CoV-2; vertical transmission
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MDPI and ACS Style

Cosma, S.; Carosso, A.R.; Borella, F.; Cusato, J.; Bovetti, M.; Bevilacqua, F.; Carosso, M.; Gervasoni, F.; Sciarrone, A.; Marozio, L.; Revelli, A.; Rolfo, A.; Filippini, C.; Ghisetti, V.; Di Perri, G.; Benedetto, C. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics 2021, 11, 398. https://doi.org/10.3390/diagnostics11030398

AMA Style

Cosma S, Carosso AR, Borella F, Cusato J, Bovetti M, Bevilacqua F, Carosso M, Gervasoni F, Sciarrone A, Marozio L, Revelli A, Rolfo A, Filippini C, Ghisetti V, Di Perri G, Benedetto C. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics. 2021; 11(3):398. https://doi.org/10.3390/diagnostics11030398

Chicago/Turabian Style

Cosma, Stefano, Andrea R. Carosso, Fulvio Borella, Jessica Cusato, Marialuisa Bovetti, Federica Bevilacqua, Marco Carosso, Fiammetta Gervasoni, Andrea Sciarrone, Luca Marozio, Alberto Revelli, Alessandro Rolfo, Claudia Filippini, Valeria Ghisetti, Giovanni Di Perri, and Chiara Benedetto. 2021. "Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study" Diagnostics 11, no. 3: 398. https://doi.org/10.3390/diagnostics11030398

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