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Systematic Review
Peer-Review Record

Influencing Cardiovascular Outcomes through Heart Rate Variability Modulation: A Systematic Review

Diagnostics 2021, 11(12), 2198; https://doi.org/10.3390/diagnostics11122198
by Alexandru Burlacu 1,2,3,†, Crischentian Brinza 1,2,†, Iolanda Valentina Popa 1,*, Adrian Covic 1,4 and Mariana Floria 1,5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Diagnostics 2021, 11(12), 2198; https://doi.org/10.3390/diagnostics11122198
Submission received: 25 October 2021 / Revised: 22 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021

Round 1

Reviewer 1 Report

The review is well written and the methodological approach is correct. I have only a few suggestions:

- the recent technological advent of the last decades introduces wrist-worn devices that permit recording RR data during daily life. I think that could be interesting to add some description about these devices and their utility in assessing the cardiac health status of the population.

- I think that it is better to explain in the introduction and results sections the protocol of HRV-biofeedback intervention. Did the studies perform the same protocol? If not, please describe the different protocols.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

In the present manuscript, authors investigate a very interesting issue in cardiovascular diseases: the role of heart rate variability in hypertension, CAD and HF. The analysis is well performed and give very interesting feedback for application in clinical practice. The only major issue is the routine use in the real world because a specific training should be necesessary. Thus, I would like to suggest the authors to include in their discussion all the potential warnings for the use in clinical practice

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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