Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Histopathology | Frequency |
---|---|
HCC | 38 |
CCC | 4 |
Metastasis | 59 |
Lymphoma | 4 |
HCC/CCC mixed type | 4 |
Hemangioma | 3 |
Cyst | 2 |
Abscess | 3 |
Hepatitis | 4 |
Fibrosis | 10 |
Cirrhosis | 9 |
Candida infection | 1 |
FNH | 2 |
Hemangioma/FNH mixed type | 1 |
Echinococcus cyst | 1 |
Focal hepatic steatosis | 3 |
Other reactive changes | 3 |
Inconspicuous | 13 |
Total (n = 160) | CEUS Positive | CEUS Negative | ||
---|---|---|---|---|
Sensitivity | ||||
Malignant | n = 109 | 103 | 6 | 94.5% |
Specificity | ||||
Benign | n = 51 | 15 | 36 | 70.6% |
TPR/ Concordance | TNR/ 1-Discordance | |||
87.3% | 85.7% |
Misclassification | Histopathology |
---|---|
False positive | Fibrotic lesions: n = 7 |
Cirrhotic lesions: n = 3 | |
No pathologic changes: n = 2 | |
Adenoma: n = 1 | |
Reactive changes: n = 1 | |
Abscess: n = 1 | |
False negative | HCC: n = 4 |
Neuroendocrine tumor (Metastasis): n = 1 | |
Adenoma carcinoma (Metastasis): n = 1 |
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Geyer, T.; Clevert, D.-A.; Schwarz, S.; Reidler, P.; Gassenmaier, S.; Knösel, T.; Rübenthaler, J.; Schwarze, V.; Armbruster, M. Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics. Diagnostics 2021, 11, 35. https://doi.org/10.3390/diagnostics11010035
Geyer T, Clevert D-A, Schwarz S, Reidler P, Gassenmaier S, Knösel T, Rübenthaler J, Schwarze V, Armbruster M. Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics. Diagnostics. 2021; 11(1):35. https://doi.org/10.3390/diagnostics11010035
Chicago/Turabian StyleGeyer, Thomas, Dirk-André Clevert, Sonja Schwarz, Paul Reidler, Sebastian Gassenmaier, Thomas Knösel, Johannes Rübenthaler, Vincent Schwarze, and Marco Armbruster. 2021. "Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics" Diagnostics 11, no. 1: 35. https://doi.org/10.3390/diagnostics11010035