Next Article in Journal
Prognostic Value of Baseline Radiomic Features of 18F-FDG PET in Patients with Diffuse Large B-Cell Lymphoma
Next Article in Special Issue
Predicting Therapeutic Efficacy of Transarterial Chemoembolization with Drug-Eluting Beads for Hepatocellular Carcinoma Using Contrast-Enhanced Ultrasound
Previous Article in Journal
Head and Neck Squamous Cell Carcinoma: Epigenetic Landscape
Previous Article in Special Issue
Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
 
 
Article

Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics

1
Department of Radiology, Ludwig-Maximilians-University, 81377 Munich, Germany
2
Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, 72076 Tuebingen, Germany
3
Institute of Pathology, Ludwig-Maximilians-University, 81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 35; https://doi.org/10.3390/diagnostics11010035
Received: 8 November 2020 / Revised: 22 December 2020 / Accepted: 24 December 2020 / Published: 27 December 2020
(This article belongs to the Special Issue Abdominal Ultrasound and Treatment of Hepatocellular Carcinoma)
Background: Contrast-enhanced ultrasound (CEUS) allows for dynamic analysis of vascularization patterns of unclear hepatic lesions. Our study aimed to evaluate the diagnostic performance of CEUS for further characterizing suspicious liver lesions by comparing findings from CEUS examinations with corresponding histopathology. Methods: Between 2005 and 2016, 160 patients with unclear liver lesions underwent CEUS followed by liver biopsy. All examinations were performed by an experienced consultant radiologist (EFSUMB Level 3) and included native B-mode ultrasound, Color Doppler, and CEUS. A second-generation blood pool contrast agent was applied for CEUS. Results: CEUS was successfully performed in all patients without occurrence of any adverse side effects. CEUS showed a sensitivity of 94.5%, a specificity of 70.6%, a true positive rate of 87.3%, and a true negative rate of 85.7% compared to histopathological results as the reference standard. Conclusions: CEUS represents a safe imaging modality with a high diagnostic accuracy in assessing both—benign and malignant—liver lesions compared to corresponding histopathological results. View Full-Text
Keywords: CEUS; contrast-enhanced ultrasound; liver; biopsy; hepatocellular carcinoma CEUS; contrast-enhanced ultrasound; liver; biopsy; hepatocellular carcinoma
Show Figures

Figure 1

MDPI and ACS Style

Geyer, T.; Clevert, D.-A.; Schwarz, S.; Reidler, P.; Gassenmaier, S.; Knösel, T.; Rübenthaler, J.; Schwarze, V.; Armbruster, M. Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics. Diagnostics 2021, 11, 35. https://doi.org/10.3390/diagnostics11010035

AMA Style

Geyer T, Clevert D-A, Schwarz S, Reidler P, Gassenmaier S, Knösel T, Rübenthaler J, Schwarze V, Armbruster M. Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics. Diagnostics. 2021; 11(1):35. https://doi.org/10.3390/diagnostics11010035

Chicago/Turabian Style

Geyer, Thomas, Dirk-André Clevert, Sonja Schwarz, Paul Reidler, Sebastian Gassenmaier, Thomas Knösel, Johannes Rübenthaler, Vincent Schwarze, and Marco Armbruster. 2021. "Diagnostic Value of CEUS Prompting Liver Biopsy: Histopathological Correlation of Hepatic Lesions with Ambiguous Imaging Characteristics" Diagnostics 11, no. 1: 35. https://doi.org/10.3390/diagnostics11010035

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop