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Article

Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty

1
Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Center Otwock, 05-400 Otwock, Poland
2
Department and Faculty of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
M.B. and A.P. contributed equally to this manuscript.
Diagnostics 2021, 11(1), 133; https://doi.org/10.3390/diagnostics11010133
Received: 9 December 2020 / Revised: 9 January 2021 / Accepted: 14 January 2021 / Published: 16 January 2021
(This article belongs to the Special Issue Pulmonary Hypertension: Diagnosis and Management)
Background: The aim of the study was to assess soluble ST2 (sST2) concentration and its dynamic changes in the periprocedural period in patients with chronic thromboembolic pulmonary hypertension (CTEPH) treated with balloon pulmonary angioplasty (BPA). Methods: We prospectively analyzed 57 procedures of BPA performed in 37 patients with CTEPH. Biomarkers, such as N-terminal pro B-type natriuretic peptide (NT-proBNP), troponin T (TnT), and sST2 were assessed at four time points: Before the BPA procedure, 24 h and 48 h after the procedure, and at the discharge from hospital. Each postprocedural period was assessed for complications. Results: Before the BPA procedure, median sST2 concentration was 26.56 ng/mL (IQR: 16.66–40.83 ng/mL). sST2 concentration was significantly higher 24 h and 48 h after the BPA compared to the baseline measurements (33.31 ng/mL (IQR: 20.81–62.56), p = 0.000 and 27.45 ng/mL (IQR: 17.66–54.45), p = 0.028, respectively). sST2 level 24 h after the BPA procedure was significantly higher in the group with complications compared to the group without complications in the postprocedural period (97.66 ng/mL (IQR: 53.07–126.18) vs. 26.86 ng/mL (IQR: 19.10–40.12), p = 0.000). Conclusions: sST2 concentration in patients with CTEPH treated with BPA changes significantly in the postprocedural period and is significantly higher in the group with complications in postprocedural period. View Full-Text
Keywords: chronic thromboembolic pulmonary hypertension; balloon pulmonary angioplasty; soluble ST2 chronic thromboembolic pulmonary hypertension; balloon pulmonary angioplasty; soluble ST2
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MDPI and ACS Style

Banaszkiewicz, M.; Pietrasik, A.; Florczyk, M.; Kędzierski, P.; Piłka, M.; Mańczak, R.; Kochman, J.; Opolski, G.; Torbicki, A.; Kurzyna, M.; Darocha, S. Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty. Diagnostics 2021, 11, 133. https://doi.org/10.3390/diagnostics11010133

AMA Style

Banaszkiewicz M, Pietrasik A, Florczyk M, Kędzierski P, Piłka M, Mańczak R, Kochman J, Opolski G, Torbicki A, Kurzyna M, Darocha S. Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty. Diagnostics. 2021; 11(1):133. https://doi.org/10.3390/diagnostics11010133

Chicago/Turabian Style

Banaszkiewicz, Marta, Arkadiusz Pietrasik, Michał Florczyk, Piotr Kędzierski, Michał Piłka, Rafał Mańczak, Janusz Kochman, Grzegorz Opolski, Adam Torbicki, Marcin Kurzyna, and Szymon Darocha. 2021. "Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty" Diagnostics 11, no. 1: 133. https://doi.org/10.3390/diagnostics11010133

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