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Article

Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up

by
Assunta Pozzuoli
1,*,†,
Antonio Berizzi
2,†,
Alberto Crimì
2,
Elisa Belluzzi
1,*,
Anna Chiara Frigo
3,
Giorgio De Conti
4,
Annamaria Nicolli
5,
Andrea Trevisan
5,
Carlo Biz
2 and
Pietro Ruggieri
2
1
Laboratory of Musculoskeletal Pathology and Oncology, Orthopaedic and Traumatologic Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
2
Orthopaedic and Traumatologic Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
3
Epidemiology and Public Health Unit, Department of Cardiac Thoracic Vascular Sciences and Public Health, Biostatistics, University of Padova, Via Loredan 18, 35131 Padova, Italy
4
Department of Radiology, University Hospital of Padova, Via Giustiniani 2, 35128 Padova, Italy
5
Laboratory of Industrial Toxicology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2020, 10(11), 941; https://doi.org/10.3390/diagnostics10110941
Submission received: 13 October 2020 / Revised: 10 November 2020 / Accepted: 11 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Hip Disease: Diagnosis, Treatment, and Management)
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Abstract

Total hip arthroplasty (THA) with metal-on-metal (MoM) bearings have shown problems of biocompatibility linked to metal ion release at the local level causing an adverse reaction to metal debris (ARMD) and at a systemic level. The aim of this study was to evaluate clinical and radiological outcomes, and metal ion concentrations in the blood and urine of patients who underwent THA with the LIMA Met-Met hip system. Patients with ceramic-on-ceramic (CoC) bearings were included as a control group. In this study, 68 patients were enrolled: 34 with MoM THAs and 34 with CoC THAs. Patients were evaluated clinically (Harris Hip Score, SF-36) and radiologically at a median of 7.4 years after surgery. Whole blood and urinary cobalt and chromium levels were also assessed. Both types of implants were comparable in terms of clinical and functional results. Ion levels were significantly higher in the MoM group compared with CoC group 7 years after surgery. No correlations were found between metal ion levels and patient demographics, functional and radiological outcomes, and prosthesis features. Patient monitoring is thus advised to establish if prosthesis revision is necessary, especially in the case of MoM THA.
Keywords: total hip arthroplasty; cobalt; chromium; metal-on-metal; ceramic-on-ceramic total hip arthroplasty; cobalt; chromium; metal-on-metal; ceramic-on-ceramic

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MDPI and ACS Style

Pozzuoli, A.; Berizzi, A.; Crimì, A.; Belluzzi, E.; Frigo, A.C.; Conti, G.D.; Nicolli, A.; Trevisan, A.; Biz, C.; Ruggieri, P. Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up. Diagnostics 2020, 10, 941. https://doi.org/10.3390/diagnostics10110941

AMA Style

Pozzuoli A, Berizzi A, Crimì A, Belluzzi E, Frigo AC, Conti GD, Nicolli A, Trevisan A, Biz C, Ruggieri P. Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up. Diagnostics. 2020; 10(11):941. https://doi.org/10.3390/diagnostics10110941

Chicago/Turabian Style

Pozzuoli, Assunta, Antonio Berizzi, Alberto Crimì, Elisa Belluzzi, Anna Chiara Frigo, Giorgio De Conti, Annamaria Nicolli, Andrea Trevisan, Carlo Biz, and Pietro Ruggieri. 2020. "Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up" Diagnostics 10, no. 11: 941. https://doi.org/10.3390/diagnostics10110941

APA Style

Pozzuoli, A., Berizzi, A., Crimì, A., Belluzzi, E., Frigo, A. C., Conti, G. D., Nicolli, A., Trevisan, A., Biz, C., & Ruggieri, P. (2020). Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up. Diagnostics, 10(11), 941. https://doi.org/10.3390/diagnostics10110941

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