Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Fine-Needle Aspiration versus Standard Fine-Needle Aspiration in Pancreatic Masses: A Propensity Score Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. EUS Technique
2.3. Outcomes
2.4. Statistical Analysis
3. Results
3.1. Patients
3.2. Diagnostic Performance
3.3. Subgroup Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Baseline Patients’ Characteristics before Propensity Score Matching | |||
---|---|---|---|
Variable | CH-EUS-FNA (n = 112) | EUS-FNA (n = 250) | p Value |
Age (years) | 67 ± 5 | 65 ± 10 | 0.58 |
Gender: Male | 65 (58%) | 150 (60%) | 0.72 |
Mass location Head/uncinate Body/tail | 78 (69.6%) 34 (30.4%) | 167 (66.8%) 83 (33.2%) | 0.59 |
Mass size (cm) | 3.4 ± 1.1 | 3.1 ± 0.9 | 0.12 |
Diagnosis adenocarcinoma NET benign | 81 (72.3%) 9 (8%) 22 (19.7%) | 185 (74%) 25 (10%) 40 (16%) | 0.62 |
Baseline Patients’ Characteristics after Propensity Score Matching | |||
Variable | CH-EUS-FNA (n = 103) | EUS-FNA (n = 103) | p Value |
Age (years) | 66 ± 6 | 66 ± 8 | 0.91 |
Gender: Male | 57 (55.3%) | 56 (54.3%) | 0.88 |
Mass location Head/uncinate Body/tail | 71 (68.9%) 32 (31.1%) | 71 (68.9%) 32 (31.1%) | 1.0 |
Mass size (cm) | 3.2 ± 1.1 | 3.2 ± 1 | 0.93 |
Diagnosis adenocarcinoma NET benign | 76 (73.9%) 7 (6.7%) 20 (19.4%) | 76 (73.9%) 7 (6.7%) 20 (19.4%) | 1.0 |
CH-EUS-FNA (103 Patients) | EUS-FNA (103 Patients) | p-Value a | |
---|---|---|---|
True positive | 78 | 72 | 0.34 |
True negative | 14 | 13 | 0.83 |
False positive | 0 | 0 | 1.0 |
False negative/inadequate samples | 11 | 18 | 0.16 |
Sensitivity | 87.6% (78.9–93.6%) | 80% (70.2–87.7%) | 0.18 |
Specificity | 100% | 100% | 1.0 |
PPV | 100% | 100% | 1.0 |
NPV | 56% (42.2–68.8%) | 41.5% (32.3–52.2%) | 0.06 |
Accuracy | 89.3% (81.6–94.5%) | 82.5% (73.8–89.3%) | 0.11 |
Sample adequacy | 94.1% | 91.2% | 0.42 |
Histologic core procurement | 33% | 28.1% | 0.44 |
Number of passes | 2.4 ± 0.6 | 2.7 ± 0.8 | 0.76 |
CH-EUS-FNA | EUS-FNA | p-Value a | |
---|---|---|---|
Sensitivity | |||
≤1.5 cm (34 patients) | 87% | 80.4% | 0.20 |
>1.5 cm (69 patients) | 88% | 80.1% | 0.21 |
≤2 cm (45 patients) | 87.3% | 81.2% | 0.28 |
>2 cm (58 patients) | 88.1% | 80.5% | 0.37 |
Hypoenhanced (73 patients) | 86.5% | -- | 0.74 * |
Iso/Hyperenhanced (30 patients) | 88.9% | -- | |
Accuracy | |||
≤1.5 cm (34 patients) | 87.5% | 82% | 0.39 |
>1.5 cm (69 patients) | 90.3% | 83.1% | 0.35 |
≤2 cm (45 patients) | 88.5% | 81.3% | 0.15 |
>2 cm (58 patients) | 90.1% | 83.8% | 0.27 |
Hypoenhanced (73 patients) | 88.7% | -- | 0.86 * |
Iso/Hyperenhanced (30 patients) | 89.9% | -- | |
Sample adequacy | |||
≤1.5 cm (34 patients) | 92.4% | 89% | 0.63 |
>1.5 cm (69 patients) | 96% | 93% | 0.44 |
≤2 cm (45 patients) | 93.4% | 90.3% | 0.59 |
>2 cm (58 patients) | 94.7% | 92.4% | 0.61 |
Hypoenhanced (73 patients) | 93.8% | -- | 0.86 * |
Iso/Hyperenhanced (30 patients) | 94.7% | -- |
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Facciorusso, A.; Cotsoglou, C.; Chierici, A.; Mare, R.; Crinò, S.F.; Muscatiello, N. Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Fine-Needle Aspiration versus Standard Fine-Needle Aspiration in Pancreatic Masses: A Propensity Score Analysis. Diagnostics 2020, 10, 792. https://doi.org/10.3390/diagnostics10100792
Facciorusso A, Cotsoglou C, Chierici A, Mare R, Crinò SF, Muscatiello N. Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Fine-Needle Aspiration versus Standard Fine-Needle Aspiration in Pancreatic Masses: A Propensity Score Analysis. Diagnostics. 2020; 10(10):792. https://doi.org/10.3390/diagnostics10100792
Chicago/Turabian StyleFacciorusso, Antonio, Christian Cotsoglou, Andrea Chierici, Ruxandra Mare, Stefano Francesco Crinò, and Nicola Muscatiello. 2020. "Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Fine-Needle Aspiration versus Standard Fine-Needle Aspiration in Pancreatic Masses: A Propensity Score Analysis" Diagnostics 10, no. 10: 792. https://doi.org/10.3390/diagnostics10100792