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10.3390/life16050796
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Review

The Role of Next-Generation Sequencing in Cardiovascular Disease: A New Era of Precision Cardiology

by
Konstantinos Agiannitopoulos
1,*,†,
Anastasios Papageorgiou
2,3,†,
Elisavet Kouvidi
4,
Eleni Kalampoka
5,
Anna Papadopoulou
5,
Anastassios Philippou
2,
Stavroula Papadodima
6,
Lubomir L. Traikov
3 and
Dimitrios C. Angouras
7
1
Division of Genetics & Biotechnology, Department of Biology, National and Kapodistrian University of Athens, 15772 Athens, Greece
2
Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
3
Department of Medical Physics and Biophysics, Medical University, 1431 Sofia, Bulgaria
4
Department of Genetics, Institute of Child Health, 11527 Athens, Greece
5
Laboratory of Clinical Biochemistry, Medical School, University General Hospital ‘Attikon’, National and Kapodistrian University of Athens, 12462 Athens, Greece
6
Department of Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
7
Department of Cardiac Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2026, 16(5), 796; https://doi.org/10.3390/life16050796
Submission received: 4 March 2026 / Revised: 30 March 2026 / Accepted: 8 May 2026 / Published: 10 May 2026
(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition)
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Abstract

Cardiovascular diseases (CVDs) are the foremost contributor to global mortality, with a significant inherited factor that has long been recognized but only recently become decipherable. Next-generation sequencing (NGS) has transformed the study of cardiovascular genetics, allowing researchers to move beyond single-gene analyses toward comprehensive assessments of both rare and common genetic variations. This review summarizes how NGS informs clinical practice, from the molecular diagnosis of inherited cardiac disorders and risk prediction using polygenic models to emerging applications in precision therapeutics. It also discusses analytical and ethical challenges and highlights new technologies, such as long-read and single-cell sequencing, that are likely to further advance precision cardiology.
Keywords: next-generation sequencing; cardiovascular disease; precision medicine; polygenic risk score; pharmacogenomics next-generation sequencing; cardiovascular disease; precision medicine; polygenic risk score; pharmacogenomics

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MDPI and ACS Style

Agiannitopoulos, K.; Papageorgiou, A.; Kouvidi, E.; Kalampoka, E.; Papadopoulou, A.; Philippou, A.; Papadodima, S.; Traikov, L.L.; Angouras, D.C. The Role of Next-Generation Sequencing in Cardiovascular Disease: A New Era of Precision Cardiology. Life 2026, 16, 796. https://doi.org/10.3390/life16050796

AMA Style

Agiannitopoulos K, Papageorgiou A, Kouvidi E, Kalampoka E, Papadopoulou A, Philippou A, Papadodima S, Traikov LL, Angouras DC. The Role of Next-Generation Sequencing in Cardiovascular Disease: A New Era of Precision Cardiology. Life. 2026; 16(5):796. https://doi.org/10.3390/life16050796

Chicago/Turabian Style

Agiannitopoulos, Konstantinos, Anastasios Papageorgiou, Elisavet Kouvidi, Eleni Kalampoka, Anna Papadopoulou, Anastassios Philippou, Stavroula Papadodima, Lubomir L. Traikov, and Dimitrios C. Angouras. 2026. "The Role of Next-Generation Sequencing in Cardiovascular Disease: A New Era of Precision Cardiology" Life 16, no. 5: 796. https://doi.org/10.3390/life16050796

APA Style

Agiannitopoulos, K., Papageorgiou, A., Kouvidi, E., Kalampoka, E., Papadopoulou, A., Philippou, A., Papadodima, S., Traikov, L. L., & Angouras, D. C. (2026). The Role of Next-Generation Sequencing in Cardiovascular Disease: A New Era of Precision Cardiology. Life, 16(5), 796. https://doi.org/10.3390/life16050796

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