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Volume 15
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Systematic Review

The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses

by
Emmanouil Maragkoudakis
1,2,*,
Theodoros Panoskaltsis
3,
Kitty Pavlakis
4,
Maria Grenzelia
2,
Evangelia Kavoura
4,
Georgios Papageorgiou
5,
Ioannis Georgakopoulos
6,
Andromachi Kougioumtzopoulou
1,
Efrosyni Kypraiou
1,
Nikolaos Trogkanis
1,
Evangelos Maragkoudakis
2,
Vassilis Kouloulias
1 and
Anna Zygogianni
6
1
Department of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece
2
Radiation Oncology Centre, Iaso General Clinic, 15123 Athens, Greece
3
Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
4
K Pathology Department, IASO Women’s Hospital, 15123 Athens, Greece
5
Second Medical Oncology Department, Iaso General Clinic, 15123 Athens, Greece
6
Radiation Oncology Unit, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
Life 2025, 15(7), 1013; https://doi.org/10.3390/life15071013
Submission received: 24 March 2025 / Revised: 20 June 2025 / Accepted: 24 June 2025 / Published: 25 June 2025
(This article belongs to the Special Issue Gynecologic Oncology: Recent Advances and Future Perspectives)
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Abstract

Background/Objectives: Definitive radiotherapy (RT) is a frequently employed salvage option in early-stage, endometrial cancer (EC) loco-regional recurrence patients. Local control (LC) and survival rates are highly variable in the literature. The aim of this review is to assess the impact of modern salvage radiotherapy (SRT) in this group of patients. Methods: A systematic review of the literature was performed, focusing on studies that included EC local recurrence patients receiving SRT after 2000 to reflect advances in radiotherapy techniques. Our report followed the principles as outlined in the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Nine studies were included in our analysis with a total sample size of 648 patients. Conclusions: SRT offers excellent LC rates in this group of patients with minimal ≥ grade 3 toxicity. Salvage rates are limited by the presence of well-known risk factors for loco-regional relapses, with distant control being the primary mode of failure, resulting in lower survival rates. The decision to omit adjuvant RT should be weighed against the anticipated salvage outcomes in case of relapse.
Keywords: uterine cancer; endometrial cancer recurrence; salvage radiotherapy; salvage brachytherapy; vaginal relapse; novel treatment strategies uterine cancer; endometrial cancer recurrence; salvage radiotherapy; salvage brachytherapy; vaginal relapse; novel treatment strategies

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MDPI and ACS Style

Maragkoudakis, E.; Panoskaltsis, T.; Pavlakis, K.; Grenzelia, M.; Kavoura, E.; Papageorgiou, G.; Georgakopoulos, I.; Kougioumtzopoulou, A.; Kypraiou, E.; Trogkanis, N.; et al. The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses. Life 2025, 15, 1013. https://doi.org/10.3390/life15071013

AMA Style

Maragkoudakis E, Panoskaltsis T, Pavlakis K, Grenzelia M, Kavoura E, Papageorgiou G, Georgakopoulos I, Kougioumtzopoulou A, Kypraiou E, Trogkanis N, et al. The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses. Life. 2025; 15(7):1013. https://doi.org/10.3390/life15071013

Chicago/Turabian Style

Maragkoudakis, Emmanouil, Theodoros Panoskaltsis, Kitty Pavlakis, Maria Grenzelia, Evangelia Kavoura, Georgios Papageorgiou, Ioannis Georgakopoulos, Andromachi Kougioumtzopoulou, Efrosyni Kypraiou, Nikolaos Trogkanis, and et al. 2025. "The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses" Life 15, no. 7: 1013. https://doi.org/10.3390/life15071013

APA Style

Maragkoudakis, E., Panoskaltsis, T., Pavlakis, K., Grenzelia, M., Kavoura, E., Papageorgiou, G., Georgakopoulos, I., Kougioumtzopoulou, A., Kypraiou, E., Trogkanis, N., Maragkoudakis, E., Kouloulias, V., & Zygogianni, A. (2025). The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses. Life, 15(7), 1013. https://doi.org/10.3390/life15071013

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