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Article

Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience

by
Kosta Cerović
1,2,
Benjamin Hadžialjević
2,3,
Simon Hawlina
1,2 and
Blaž Trotovšek
2,3,*
1
Clinical Department of Urology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
2
Department of Surgery, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
3
Clinical Department of Abdominal Surgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Life 2024, 14(10), 1319; https://doi.org/10.3390/life14101319
Submission received: 9 September 2024 / Revised: 1 October 2024 / Accepted: 16 October 2024 / Published: 17 October 2024
(This article belongs to the Section Medical Research)

Abstract

Combined liver–kidney transplantation (CLKT) has evolved as a therapeutic option for patients with concurrent end-stage liver and renal diseases. This study evaluates the perioperative and long-term outcomes of CLKT at a single center in Slovenia, highlighting the challenges and successes of simultaneous organ transplantation. We retrospectively analyzed all patients undergoing simultaneous CLKT at the University Medical Centre Ljubljana from April 2014 to June 2023. Data on demographics, cause of liver and kidney disease, operative details, postoperative complications, patient and graft survival, and follow-up were collected and analyzed. Five patients aged 27 to 60 years underwent CLKT within the study period. All transplants involved deceased donors with whole-liver grafts. Indications for CLKT were polycystic liver disease (n = 3), Caroli’s disease (n = 1), and alcoholic cirrhosis (n = 1). The mean follow-up duration was 45.2 months, with a 100% survival rate. The incidence of surgical and postoperative complications was low. This pioneering series of simultaneous CLKTs in Slovenia demonstrates the feasibility and effectiveness of the procedure in smaller transplant centers. Despite challenges, including T cell-mediated kidney rejection and surgical complications, the study emphasizes the importance of comprehensive postoperative care and management in optimizing outcomes for CLKT recipients.
Keywords: liver transplant; kidney transplant; combined liver–kidney transplantation; simultaneous organ transplantation; transplant outcomes; postoperative complications liver transplant; kidney transplant; combined liver–kidney transplantation; simultaneous organ transplantation; transplant outcomes; postoperative complications

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MDPI and ACS Style

Cerović, K.; Hadžialjević, B.; Hawlina, S.; Trotovšek, B. Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience. Life 2024, 14, 1319. https://doi.org/10.3390/life14101319

AMA Style

Cerović K, Hadžialjević B, Hawlina S, Trotovšek B. Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience. Life. 2024; 14(10):1319. https://doi.org/10.3390/life14101319

Chicago/Turabian Style

Cerović, Kosta, Benjamin Hadžialjević, Simon Hawlina, and Blaž Trotovšek. 2024. "Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience" Life 14, no. 10: 1319. https://doi.org/10.3390/life14101319

APA Style

Cerović, K., Hadžialjević, B., Hawlina, S., & Trotovšek, B. (2024). Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience. Life, 14(10), 1319. https://doi.org/10.3390/life14101319

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