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Systematic Review

Gastroenterological Manifestations of Immunoglobulin G Subclass 4-Related Disease—Epidemiology, Clinical Manifestations, Diagnosis and Treatment

by
Jorge Lucas de Sousa Moreira
1,
Sarah Maria Bacurau Barbosa
1,
Pedro Lucas Gomes Moreira de Meneses
1,
Pedro Garcia Dias de Barros
1,
Samuel de Sá Barreto Lima
1,
Damiao Maroto Gomes Junior
2,
Gledson Micael da Silva Leite
2,
Jacob Oliveira Duarte
1,2,
Galba Matos Cardoso de Alencar Junior
3,
Maria Auxiliadora Ferreira Brito Almino
1,4,
José Matos Cruz
5,
Hermes Melo Teixeira Batista
1,
Estelita Lima Cândido
1,2,
Gislene Farias de Oliveira
1,
Hellen Lúcia Macedo Cruz
1 and
Jucier Gonçalves Júnior
1,6,*
1
School of Medicine, Universidade Federal do Cariri (UFCA), Barbalha 63180-000, CE, Brazil
2
Programa de Pós-Graduação em Ciências da Saúde, School of Medicine, Universidade Federal do Cariri (UFCA), Barbalha 63180-000, CE, Brazil
3
School of Dentistry, CECAPE, Juazeiro do Norte 63024-015, CE, Brazil
4
Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Sergipe (UFS), Aracaju 49032-490, SE, Brazil
5
Programa de Pós-Graduação em Biotecnologia em Saúde Humana e Animal, Universidade Estadual do Ceará (UECE), Fortaleza 60356-000, CE, Brazil
6
Department of Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo 01246-903, SP, Brazil
*
Author to whom correspondence should be addressed.
Life 2023, 13(8), 1725; https://doi.org/10.3390/life13081725
Submission received: 4 July 2023 / Revised: 3 August 2023 / Accepted: 4 August 2023 / Published: 11 August 2023
(This article belongs to the Special Issue Rheumatology and Immunity Research: From Mechanisms, Diagnosis to Clinical Treatment)
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Abstract

Despite causing high morbidity, IgG4-related disease (IgG4-RD) and its gastroenterological manifestations lack better and greater theoretical contributions. Therefore, the objective of this work was to evaluate the clinical–epidemiological, diagnostic and treatment aspects of the gastrointestinal manifestations of this disease. A systematic review was carried out using the PubMed, Scopus and Embase databases between January 2012 and March 2023 with the following descriptors: “Immunoglobulin G4-Related Disease” (MeSH) AND #2 “Gastrointestinal Tract” (MeSH). Our data collection grouped a total of 3607 patients from mostly epidemiological cohort studies and cross-sectional follow-ups. In the subgroup analysis, IgG4-RD was associated with male gender, with an estimated prevalence between 54% and 80%. In our findings, the prevalence by topography was presented in the following ranges: lacrimal glands (17–57%); salivary glands (28–72%); pancreas (19–60%); biliary tract (5–40%); retroperitoneal cavity (9–43%). Longitudinal studies are needed to better map the natural history of the gastrointestinal manifestations of IgG4-RD and enable the formulation of individualized treatments.
Keywords: diagnosis; immunoglobulin G4-related disease; gastrointestinal tract; epidemiology; systematic review diagnosis; immunoglobulin G4-related disease; gastrointestinal tract; epidemiology; systematic review

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MDPI and ACS Style

Moreira, J.L.d.S.; Barbosa, S.M.B.; Meneses, P.L.G.M.d.; Barros, P.G.D.d.; Lima, S.d.S.B.; Gomes Junior, D.M.; Leite, G.M.d.S.; Duarte, J.O.; Alencar Junior, G.M.C.d.; Almino, M.A.F.B.; et al. Gastroenterological Manifestations of Immunoglobulin G Subclass 4-Related Disease—Epidemiology, Clinical Manifestations, Diagnosis and Treatment. Life 2023, 13, 1725. https://doi.org/10.3390/life13081725

AMA Style

Moreira JLdS, Barbosa SMB, Meneses PLGMd, Barros PGDd, Lima SdSB, Gomes Junior DM, Leite GMdS, Duarte JO, Alencar Junior GMCd, Almino MAFB, et al. Gastroenterological Manifestations of Immunoglobulin G Subclass 4-Related Disease—Epidemiology, Clinical Manifestations, Diagnosis and Treatment. Life. 2023; 13(8):1725. https://doi.org/10.3390/life13081725

Chicago/Turabian Style

Moreira, Jorge Lucas de Sousa, Sarah Maria Bacurau Barbosa, Pedro Lucas Gomes Moreira de Meneses, Pedro Garcia Dias de Barros, Samuel de Sá Barreto Lima, Damiao Maroto Gomes Junior, Gledson Micael da Silva Leite, Jacob Oliveira Duarte, Galba Matos Cardoso de Alencar Junior, Maria Auxiliadora Ferreira Brito Almino, and et al. 2023. "Gastroenterological Manifestations of Immunoglobulin G Subclass 4-Related Disease—Epidemiology, Clinical Manifestations, Diagnosis and Treatment" Life 13, no. 8: 1725. https://doi.org/10.3390/life13081725

APA Style

Moreira, J. L. d. S., Barbosa, S. M. B., Meneses, P. L. G. M. d., Barros, P. G. D. d., Lima, S. d. S. B., Gomes Junior, D. M., Leite, G. M. d. S., Duarte, J. O., Alencar Junior, G. M. C. d., Almino, M. A. F. B., Cruz, J. M., Batista, H. M. T., Cândido, E. L., Oliveira, G. F. d., Cruz, H. L. M., & Gonçalves Júnior, J. (2023). Gastroenterological Manifestations of Immunoglobulin G Subclass 4-Related Disease—Epidemiology, Clinical Manifestations, Diagnosis and Treatment. Life, 13(8), 1725. https://doi.org/10.3390/life13081725

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