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Article

The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris

by
Panic D. Dragan
1,
Simic B. Ivan
2,
Davidovic Z. Goran
2,
Nikolic D. Maja
3,
Lazarevic D. Nevena
4,5,
Andjic M. Marijana
4,
Vuckovic M. Jelena
2,6,
Zornic J. Nenad
7,
Zivkovic I. Vladimir
3,5,8,
Tamara Nikolic Turnic
4,8,9,*,
Jakovljevic Lj Vladimir
3,8,10 and
Iric Cupic M. Violeta
2
1
Department of Cardiology, General Hospital Cuprija, Miodraga Novakovic 78, 35230 Cuprija, Serbia
2
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
3
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
4
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
5
Department of Clinical Pharmacology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
6
Department of Cardiology, University Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia
7
Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
8
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Medical University (Sechenov University), 34000 Kragujevac, Serbia
9
N.A. Semashko Public Health and Healthcare Department, F.F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
10
Department of Human Pathology, University I.M. Sechenov, 1st Moscow State Medical, Trubetskaya Street 8, Str. 2, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Life 2023, 13(7), 1537; https://doi.org/10.3390/life13071537
Submission received: 7 June 2023 / Revised: 29 June 2023 / Accepted: 5 July 2023 / Published: 11 July 2023
(This article belongs to the Special Issue Advances in Microvascular Research)
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Abstract

(1) Background: We aimed to analyze the oxidative status of patients with unstable angina pectoris (UA), as well as to determine the correlation of these parameters between coronary arterial and peripheral venous blood samples. (2) Methods: The study included 47 human subjects with UA and 45 control subjects. We performed clinical examinations, hemodynamic and coronary angiography measures. Also, in the blood samples, we measured routine laboratory markers and the concentration of pro-oxidants: index of lipid peroxidation (TBARS), superoxide anion radical (O2−), hydrogen peroxide (H2O2) and nitrites (NO2−), while antioxidant parameters were determined from red blood cells: reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). All parameters were determined spectrophotometrically. (3) Results: Significantly higher values of TBARS and all measured antioxidants SOD, CAT and GSH were observed in the coronary arterial blood of the UA group relative to coronary arterial blood of the control subjects. On the other hand, in the peripheral venous blood samples, a significantly lower GSH value was found in the UA group compared to the control. (4) Conclusions: This study has shown that the majority of changes in all measured redox markers are found in coronary blood, especially related to the activity of antioxidant components. In patients with an unstable form of angina, prooxidants (superoxide anion radical and index of lipid peroxidation) and endogenous antioxidants (catalase, superoxide dismutase and reduced glutathione) are in direct correlation with the course of ischemic disease. Future studies, where participants would be randomized depending on symptom duration, are necessary to confirm these conclusions.
Keywords: oxidative status; coronary arterial blood; peripheral venous blood; acute coronary syndrome; unstable angina pectoris oxidative status; coronary arterial blood; peripheral venous blood; acute coronary syndrome; unstable angina pectoris

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MDPI and ACS Style

Dragan, P.D.; Ivan, S.B.; Goran, D.Z.; Maja, N.D.; Nevena, L.D.; Marijana, A.M.; Jelena, V.M.; Nenad, Z.J.; Vladimir, Z.I.; Turnic, T.N.; et al. The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris. Life 2023, 13, 1537. https://doi.org/10.3390/life13071537

AMA Style

Dragan PD, Ivan SB, Goran DZ, Maja ND, Nevena LD, Marijana AM, Jelena VM, Nenad ZJ, Vladimir ZI, Turnic TN, et al. The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris. Life. 2023; 13(7):1537. https://doi.org/10.3390/life13071537

Chicago/Turabian Style

Dragan, Panic D., Simic B. Ivan, Davidovic Z. Goran, Nikolic D. Maja, Lazarevic D. Nevena, Andjic M. Marijana, Vuckovic M. Jelena, Zornic J. Nenad, Zivkovic I. Vladimir, Tamara Nikolic Turnic, and et al. 2023. "The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris" Life 13, no. 7: 1537. https://doi.org/10.3390/life13071537

APA Style

Dragan, P. D., Ivan, S. B., Goran, D. Z., Maja, N. D., Nevena, L. D., Marijana, A. M., Jelena, V. M., Nenad, Z. J., Vladimir, Z. I., Turnic, T. N., Vladimir, J. L., & Violeta, I. C. M. (2023). The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris. Life, 13(7), 1537. https://doi.org/10.3390/life13071537

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