Prolapsed Atypical Polypoid Adenomyoma—A Case Report and Literature Review

Round 1

Reviewer 1 Report

See the atached file.

Comments for author File: Comments.pdf

I suggest authors to carefully revise all throughout the text.

The manuscript must  be reviewed and corrected by a native English speaker!

Author Response

Dear reviewer, 

Firstly I want to thank you for reading and reviewing our work.

Please see the attachement

Author Response File: Author Response.docx

Reviewer 2 Report

Title is relevant for the content, but can be changed to give more scientific soundness and importance to the article. Introduction provides sufficient information, supported by up to date references, but the importance of this article and the therapeutic approach should be underlined in this chapter. Case report is present clear and supported by good images. Discussion offers an abundent literature review. Conclusions are supported by the data presented. Bibliography is up to date.

Minor english editing required

Author Response

Reviewer 3 Report

The articles presents a rare pathology. Some observations

line 266:Additionally, after surgery, the use of the LNG-IUS (levonorgestrel- 265 releasing intrauterine system) may serve a dual purpose: preventing adhesions and 266 facilitating the disappearance of the tumor [10].  

on the AAGL practice guidelines on preventing intrauterine adhesions is stipulated that if an IUD is used for adhesion prevention after ooperative hysteroscopy it should be inert not with progestins. This must be clarified

On discussion: this procedure was performed on a patient with desire to preserve her fertility. Anti adhesion options should be discussed after hysteroscoipic resection.

no comments

Author Response

Thank you very much for taking the time to read and review this manuscript

Thank you for pointing this out. The use of LNG-IUS in these rare cases is only to reduce the risk of recurrences or malignant transformation and there are no standardized treatments till now. We did not perform any hysteroscopic resection in our case and we didn’t think of focusing our discussions on other methods of prevention

Reviewer 4 Report

The topic discussed in the publication concerns extremely rare tumors occurring in the uterus. The issue discussed in the text is an interesting medical problem worth publishing. However, the text requires some corrections:

1. The figures included in the text require better descriptions, highlighting the anatomical structures presented in the pictures. 

2. The part of the text named: immunohistochemistry concerns not only immunohistochemical but also molecular diagnostics as well as tumor markers.

3. Presenting certain information (e.g. risk factors) in the form of a table will make the text more clear and reader-friendly.

4. The method of presenting the literature requires standardization in accordance with the requirements of the journal.

The text should be corrected in terms of syntax and punctuation by a native English speaker.

Author Response

Thank you very much for taking the time to read and review this manuscript. Thank you for pointing this out. We agree with this comment and we have added the anatomical description We do agree that the subtitle did not cover all the discussed points. We have also changed the suggested subtitle to "immunohistochemical and molecular diagnosis". The whole manuscript was thoroughly checked and corrected accordingly in terms of syntax and punctuation  

Reviewer 5 Report

What is the new aspect?

This is like a review article, not a case report.

Moderate editing of the English language is required.

Author Response

The particularity of our case consisted in the very young age of the patient, the absence of former engagement in sexual intercourse, the unusual size and localisation of the mass as well as the therapeutic approach of the tumor.

In the title we have have added that this is a case report followed by a literature review 

Round 2

Reviewer 1 Report

See the attached file.

Comments for author File: Comments.docx

Reviewer 5 Report

The authors' resubmitted paper has been sufficiently revised for publication in the journal.  I believe that "accept" is appropriate in the present form.