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10.3390/life13010016
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Article

Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy

by
Federico Bruno
1,2,*,
Emanuele Tommasino
3,
Alessia Catalucci
4,
Cristina Pastorelli
3,
Francesco Borea
3,
Giulia Caldarelli
3,
Mattia Bellini
3,
Pierfrancesco Badini
3,
Sara Mancini
3,
Chiara Santobuono
3,
Saverio Martino
3,
Valeria Pagliei
3,
Guglielmo Manco
5,
Davide Cerone
6,
Francesca Pistoia
3,
Pierpaolo Palumbo
2,7,
Francesco Arrigoni
1,
Ernesto Di Cesare
8,
Carmine Marini
3,
Antonio Barile
3,
Alessandra Splendiani
3 and
Carlo Masciocchi
3add Show full author list remove Hide full author list
1
Emergency Radiology, San Salvatore Hospital, 67100 L’Aquila, Italy
2
Italian Society of Medical and Intervention Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy
3
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
4
Neuroradiology and Interventional Radiology, San Salvatore Hospital, 67100 L’Aquila, Italy
5
Mediaire GmbH, 10965 Berlin, Germany
6
Neurology, San Salvatore Hospital, 67100 L’Aquila, Italy
7
Department of Diagnostic Imaging, Area of Cardiovascular and Interventional Imaging, Abruzzo Health Unit 1, 67100 L’Aquila, Italy
8
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
*
Author to whom correspondence should be addressed.
Life 2023, 13(1), 16; https://doi.org/10.3390/life13010016
Submission received: 8 October 2022 / Revised: 23 November 2022 / Accepted: 15 December 2022 / Published: 21 December 2022
(This article belongs to the Section Physiology and Pathology)
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Abstract

The purpose of the study is to quantify volumetric variations of cortical and subcortical brain structures after Vim ablation using MRgFUS, and correlate them with the patients’ clinical features and treatment outcomes. For this pilot retrospective study we enrolled 31 patients with a mean age of 70.86 years who were eligible for unilateral Vim thalamotomy. Clinical evaluation included tremor severity assessment using the FTM scale and cognitive assessment using the MoCA score. MRI data were acquired with a 3T scanner, using a dedicated 32-channel coil and acquiring a volumetric sequence of T1 3D IR FSPGR (BRAVO), before treatment and one year after MRgFUS thalamotomy. Image processing and volume data extraction were conducted with dedicated software. A volumetric analysis showed a significant reduction (p < 0.05) of the left thalamus 1 year after the treatment in patients with ET. Other significant results were found on the same side in the other nuclei of the basal ganglia and in the cerebellar cortex. In confronting the two groups (ET, PD), no significant differences were found in terms of age, FTM, MoCA scores, or brain volumes. Similarly, no significant correlations were found between the FTM and MoCA scores and the brain volumes before the treatment.
Keywords: tremor; MRgFUS thalamotomy; brain volumes; MRI tremor; MRgFUS thalamotomy; brain volumes; MRI

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MDPI and ACS Style

Bruno, F.; Tommasino, E.; Catalucci, A.; Pastorelli, C.; Borea, F.; Caldarelli, G.; Bellini, M.; Badini, P.; Mancini, S.; Santobuono, C.; et al. Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy. Life 2023, 13, 16. https://doi.org/10.3390/life13010016

AMA Style

Bruno F, Tommasino E, Catalucci A, Pastorelli C, Borea F, Caldarelli G, Bellini M, Badini P, Mancini S, Santobuono C, et al. Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy. Life. 2023; 13(1):16. https://doi.org/10.3390/life13010016

Chicago/Turabian Style

Bruno, Federico, Emanuele Tommasino, Alessia Catalucci, Cristina Pastorelli, Francesco Borea, Giulia Caldarelli, Mattia Bellini, Pierfrancesco Badini, Sara Mancini, Chiara Santobuono, and et al. 2023. "Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy" Life 13, no. 1: 16. https://doi.org/10.3390/life13010016

APA Style

Bruno, F., Tommasino, E., Catalucci, A., Pastorelli, C., Borea, F., Caldarelli, G., Bellini, M., Badini, P., Mancini, S., Santobuono, C., Martino, S., Pagliei, V., Manco, G., Cerone, D., Pistoia, F., Palumbo, P., Arrigoni, F., Di Cesare, E., Marini, C., ... Masciocchi, C. (2023). Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy. Life, 13(1), 16. https://doi.org/10.3390/life13010016

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