Next Article in Journal
3D-QSAR Studies, Molecular Docking, Molecular Dynamic Simulation, and ADMET Proprieties of Novel Pteridinone Derivatives as PLK1 Inhibitors for the Treatment of Prostate Cancer
Next Article in Special Issue
First Use of Non-Invasive Spinal Cord Stimulation in Motor Rehabilitation of Children with Spinal Muscular Atrophy
Previous Article in Journal
Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women
Previous Article in Special Issue
Transcutaneous Spinal Cord Stimulation Attenuates Blood Pressure Drops in Orthostasis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 13
Issue 1
10.3390/life13010126
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Twenty-Three Months Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex for Refractory Trigeminal Neuralgia: A Single-Case Study

by
Sascha Freigang
1,*,
Shane Fresnoza
2,3,
Christian Lehner
1,
Dominyka Jasinskaitė
4,
Kariem Mahdy Ali
1,
Karla Zaar
1 and
Michael Mokry
1
1
Department of Neurosurgery, Medical University Graz, 8036 Graz, Austria
2
Institute of Psychology, University of Graz, 8010 Graz, Austria
3
BioTechMed, 8010 Graz, Austria
4
Faculty of Medicine, Lithuanian University of Health Sciences Kaunas, 44307 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Life 2023, 13(1), 126; https://doi.org/10.3390/life13010126
Submission received: 24 November 2022 / Revised: 13 December 2022 / Accepted: 27 December 2022 / Published: 2 January 2023
(This article belongs to the Special Issue Non-invasive Neuromodulation: Past, Present and Future)
Browse Figures
Review Reports Versions Notes

Abstract

Treatment refractory or recurrent trigeminal neuralgia (TN) is a severe chronic pain illness. Single-session repetitive transcranial magnetic stimulation (rTMS) has been shown to elicit analgesic effects in several craniofacial pain syndromes, including TN. However, the safety and long-term effect of multi-session rTMS for TN have yet to be fully explored. In this study, we present a case of a patient with medical treatment-refractory TN after microvascular decompression. The patient volunteered to undergo 73 sessions of 10 Hz rTMS over 23 months. Neurovagination was used for precise localization and stimulation of the hand and face representation at the left motor cortex. The numeric pain intensity scores derived using the visual analog scale served as a daily index of treatment efficacy. The patient experienced a significant weekly reduction in pain scores, cumulating in 70.89% overall pain relief. The medication dosages were reduced and then discontinued toward the end of the intervention period. No severe adverse events were reported. From our results, we can conclude that the longitudinal multi-session application of rTMS over the hand and face area of M1 is a safe and effective method for producing long-lasting pain relief in TN. Using rTMS may thus prove helpful as an adjunct to conventional methods for treating pain in TN.
Keywords: neuromodulation; chronic pain; refractory trigeminal neuralgia; rTMS neuromodulation; chronic pain; refractory trigeminal neuralgia; rTMS

Share and Cite

MDPI and ACS Style

Freigang, S.; Fresnoza, S.; Lehner, C.; Jasinskaitė, D.; Ali, K.M.; Zaar, K.; Mokry, M. Twenty-Three Months Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex for Refractory Trigeminal Neuralgia: A Single-Case Study. Life 2023, 13, 126. https://doi.org/10.3390/life13010126

AMA Style

Freigang S, Fresnoza S, Lehner C, Jasinskaitė D, Ali KM, Zaar K, Mokry M. Twenty-Three Months Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex for Refractory Trigeminal Neuralgia: A Single-Case Study. Life. 2023; 13(1):126. https://doi.org/10.3390/life13010126

Chicago/Turabian Style

Freigang, Sascha, Shane Fresnoza, Christian Lehner, Dominyka Jasinskaitė, Kariem Mahdy Ali, Karla Zaar, and Michael Mokry. 2023. "Twenty-Three Months Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex for Refractory Trigeminal Neuralgia: A Single-Case Study" Life 13, no. 1: 126. https://doi.org/10.3390/life13010126

APA Style

Freigang, S., Fresnoza, S., Lehner, C., Jasinskaitė, D., Ali, K. M., Zaar, K., & Mokry, M. (2023). Twenty-Three Months Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex for Refractory Trigeminal Neuralgia: A Single-Case Study. Life, 13(1), 126. https://doi.org/10.3390/life13010126

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop