Next Article in Journal
The Optimization of Dietary Protein Level and Carbon Sources on Biofloc Nutritive Values, Bacterial Abundance, and Growth Performances of Whiteleg Shrimp (Litopenaeus vannamei) Juveniles
Previous Article in Journal
Salicylic Acid, a Multifaceted Hormone, Combats Abiotic Stresses in Plants
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 12
Issue 6
10.3390/life12060887
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways

by
Daniel Aguilar
1,2,
Adelaida Bosacoma
2,3,
Isabel Blanco
2,3,4,
Olga Tura-Ceide
2,3,4,5,
Anna Serrano-Mollar
2,3,6,
Joan Albert Barberà
2,3,4 and
Victor Ivo Peinado
2,3,4,6,*
1
Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREDH), 28005 Madrid, Spain
2
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3
Biomedical Research Networking Center in Respiratory Diseases (CIBERES), 28029 Madrid, Spain
4
Department of Pulmonary Medicine, Hospital Clínic, University of Barcelona, 08007 Barcelona, Spain
5
Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain
6
Department of Experimental Pathology, Institut d’Investigacions Biomèdiques de Barcelona (IIBB), CSIC-IDIBAPS, 08036 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Life 2022, 12(6), 887; https://doi.org/10.3390/life12060887
Submission received: 29 April 2022 / Revised: 2 June 2022 / Accepted: 11 June 2022 / Published: 14 June 2022
(This article belongs to the Section Physiology and Pathology)
Browse Figures
Versions Notes

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Among other sequelae, the available data indicate that many patients who recover from COVID-19 could develop fibrotic abnormalities over time. To understand the basic pathophysiology underlying the development of long-term pulmonary fibrosis in COVID-19, as well as the higher mortality rates in patients with pre-existing lung diseases, we compared the transcriptomic fingerprints among patients with COVID-19, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) using interactomic analysis. Patients who died of COVID-19 shared some of the molecular biological processes triggered in patients with IPF, such as those related to immune response, airway remodeling, and wound healing, which could explain the radiological images seen in some patients after discharge. However, other aspects of this transcriptomic profile did not resemble the profile associated with irreversible fibrotic processes in IPF. Our mathematical approach instead showed that the molecular processes that were altered in COVID-19 patients more closely resembled those observed in COPD. These data indicate that patients with COPD, who have overcome COVID-19, might experience a faster decline in lung function that will undoubtedly affect global health.
Keywords: chronic lung disease; transcriptome; interactome; cluster analysis; bioinformatic analysis; molecular pathway; inflammation chronic lung disease; transcriptome; interactome; cluster analysis; bioinformatic analysis; molecular pathway; inflammation

Share and Cite

MDPI and ACS Style

Aguilar, D.; Bosacoma, A.; Blanco, I.; Tura-Ceide, O.; Serrano-Mollar, A.; Barberà, J.A.; Peinado, V.I. Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways. Life 2022, 12, 887. https://doi.org/10.3390/life12060887

AMA Style

Aguilar D, Bosacoma A, Blanco I, Tura-Ceide O, Serrano-Mollar A, Barberà JA, Peinado VI. Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways. Life. 2022; 12(6):887. https://doi.org/10.3390/life12060887

Chicago/Turabian Style

Aguilar, Daniel, Adelaida Bosacoma, Isabel Blanco, Olga Tura-Ceide, Anna Serrano-Mollar, Joan Albert Barberà, and Victor Ivo Peinado. 2022. "Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways" Life 12, no. 6: 887. https://doi.org/10.3390/life12060887

APA Style

Aguilar, D., Bosacoma, A., Blanco, I., Tura-Ceide, O., Serrano-Mollar, A., Barberà, J. A., & Peinado, V. I. (2022). Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways. Life, 12(6), 887. https://doi.org/10.3390/life12060887

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop