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Open AccessArticle

Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD

1
Grup de Recerca GEMMAIR (AGAUR)—Medicina Aplicada, Departament de Medicina i Cirurgia, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain
2
Servei Medicina Interna, Hospital Universitari de Tarragona Joan XXIII, 43007 Tarragona, Spain
3
Servei Anatomia Patològica, Hospital Universitari de Tarragona Joan XXIII, 43007 Tarragona, Spain
4
Servei de Cirurgia, Hospital Universitari Sant Joan de Reus, Departament de Medicina i Cirurgia, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43204 Reus, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Life 2020, 10(10), 245; https://doi.org/10.3390/life10100245
Received: 25 August 2020 / Revised: 8 October 2020 / Accepted: 14 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Fatty Liver Syndrome)
Non-alcoholic fatty liver disease (NAFLD) extends from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH). Peripheral serotonin (5-HT) has become as an important regulator of different metabolic pathways. 5-HT has been related to obesity and lipid accumulation in the liver. The objective of this study was to assess the relationship between the 5-HT signaling pathway and the degree of NAFLD, as well as to investigate whether peripheral 5-HT levels are related to the hepatic and jejunal mRNA abundance of serotonin receptors (HTR) in a cohort of women with morbid obesity (MO) and NAFLD. ELISA was used to quantify the serum 5-HT from normal-weight subjects (n = 26) and patients with MO (n = 58). We used RTq-PCR analysis to evaluate the relative expression of HTR in women with MO with normal liver (n = 22), SS (n = 21), and NASH (n = 15). The 5-HT was diminished in women with MO under a hypocaloric diet, regardless of the presence of NAFLD. Additionally, we report a negative correlation of 5-HT levels with metabolic syndrome criteria, suggesting that serotonin may have a protective role in obesity. Additionally, the hepatic expression of HTR2A and HTR2B were decreased in women with MO and NAFLD, but no significant differences in the HTR jejunal expression according to the presence of NAFLD were found. View Full-Text
Keywords: serotonin; non-alcoholic fatty liver disease; morbid obesity; bariatric surgery; metabolic syndrome serotonin; non-alcoholic fatty liver disease; morbid obesity; bariatric surgery; metabolic syndrome
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MDPI and ACS Style

Binetti, J.; Bertran, L.; Riesco, D.; Aguilar, C.; Martínez, S.; Sabench, F.; Porras, J.A.; Camaron, J.; Castillo, D.D.; Richart, C.; Auguet, T. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Life 2020, 10, 245. https://doi.org/10.3390/life10100245

AMA Style

Binetti J, Bertran L, Riesco D, Aguilar C, Martínez S, Sabench F, Porras JA, Camaron J, Castillo DD, Richart C, Auguet T. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Life. 2020; 10(10):245. https://doi.org/10.3390/life10100245

Chicago/Turabian Style

Binetti, Jessica; Bertran, Laia; Riesco, David; Aguilar, Carmen; Martínez, Salomé; Sabench, Fàtima; Porras, Jose A.; Camaron, Javier; Castillo, Daniel D.; Richart, Cristóbal; Auguet, Teresa. 2020. "Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD" Life 10, no. 10: 245. https://doi.org/10.3390/life10100245

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